Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration

Julie Anne Seguin, Jordan Brennan, Emily Mangano, Shawn HayleyInstitute of Neuroscience, Carleton University, Ottawa, Ontario, CanadaAbstract: Disturbances of hippocampal plasticity, including impaired dendritic branching and reductions of neurogenesis, are provoked by stressful insults and may occu...

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Autores principales:	Julie Anne Seguin, Jordan Brennan, Emily Mangano, Shawn Hayley
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8031b6a09f6945babf33fe4350530e15
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spelling	oai:doaj.org-article:8031b6a09f6945babf33fe4350530e152021-12-02T08:18:58ZProinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration1176-63281178-2021https://doaj.org/article/8031b6a09f6945babf33fe4350530e152008-12-01T00:00:00Zhttp://www.dovepress.com/proinflammatory-cytokines-differentially-influence-adult-hippocampal-c-a2656https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Julie Anne Seguin, Jordan Brennan, Emily Mangano, Shawn HayleyInstitute of Neuroscience, Carleton University, Ottawa, Ontario, CanadaAbstract: Disturbances of hippocampal plasticity, including impaired dendritic branching and reductions of neurogenesis, are provoked by stressful insults and may occur in depression. Although corticoids likely contribute to stressor-induced reductions of neurogenesis, other signaling messengers, including pro-inflammatory cytokines might also be involved. Accordingly, the present investigation assessed whether three proinflammatory cytokines, namely interleukin-1&beta; (IL-1&beta;), IL-6, and tumor necrosis factor-&alpha; (TNF-&alpha;) (associated with depression) influenced cellular proliferation within the hippocampus. In this regard, systemic administration of TNF-&alpha; reduced 5-bromo-2-deoxyuridine (BrdU) labeling within the hippocampus, whereas IL-1&beta; and IL-6 had no such effect. However, repeated but not a single intra-hippocampal infusion of IL-6 and IL-1&beta; actually increased cellular proliferation and IL-6 infusion also enhanced microglial staining within the hippocampus. Yet, no changes in doublecortin expression were apparent, suggesting that the cytokine did not influence the birth of cells destined to become neurons. Essentially, the route of administration and chronicity of cytokine administration had a marked influence upon the nature of hippocampal alterations provoked, suggesting that cytokines may differentially regulate hippocampal plasticity in neuropsychiatric conditions.Keywords: cytokine, depression, neuroplasticity, hippocampus, stressor Julie Anne SeguinJordan BrennanEmily ManganoShawn HayleyDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 5-14 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Julie Anne Seguin Jordan Brennan Emily Mangano Shawn Hayley Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
description	Julie Anne Seguin, Jordan Brennan, Emily Mangano, Shawn HayleyInstitute of Neuroscience, Carleton University, Ottawa, Ontario, CanadaAbstract: Disturbances of hippocampal plasticity, including impaired dendritic branching and reductions of neurogenesis, are provoked by stressful insults and may occur in depression. Although corticoids likely contribute to stressor-induced reductions of neurogenesis, other signaling messengers, including pro-inflammatory cytokines might also be involved. Accordingly, the present investigation assessed whether three proinflammatory cytokines, namely interleukin-1&beta; (IL-1&beta;), IL-6, and tumor necrosis factor-&alpha; (TNF-&alpha;) (associated with depression) influenced cellular proliferation within the hippocampus. In this regard, systemic administration of TNF-&alpha; reduced 5-bromo-2-deoxyuridine (BrdU) labeling within the hippocampus, whereas IL-1&beta; and IL-6 had no such effect. However, repeated but not a single intra-hippocampal infusion of IL-6 and IL-1&beta; actually increased cellular proliferation and IL-6 infusion also enhanced microglial staining within the hippocampus. Yet, no changes in doublecortin expression were apparent, suggesting that the cytokine did not influence the birth of cells destined to become neurons. Essentially, the route of administration and chronicity of cytokine administration had a marked influence upon the nature of hippocampal alterations provoked, suggesting that cytokines may differentially regulate hippocampal plasticity in neuropsychiatric conditions.Keywords: cytokine, depression, neuroplasticity, hippocampus, stressor
format	article
author	Julie Anne Seguin Jordan Brennan Emily Mangano Shawn Hayley
author_facet	Julie Anne Seguin Jordan Brennan Emily Mangano Shawn Hayley
author_sort	Julie Anne Seguin
title	Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
title_short	Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
title_full	Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
title_fullStr	Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
title_full_unstemmed	Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
title_sort	proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/8031b6a09f6945babf33fe4350530e15
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Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration

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