ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL

Understanding the molecular events controlling melanoma progression are necessary to find improved therapeutics. Here, the authors report oncogenic SOX2-GLI1 transcriptional complex to drive melanoma invasion through the induction of the sialyltransferase ST3GAL1, and report ST3GAL1-AXL axis as driv...

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Autores principales:	Silvia Pietrobono, Giulia Anichini, Cesare Sala, Fabrizio Manetti, Luciana L. Almada, Sara Pepe, Ryan M. Carr, Brooke D. Paradise, Jann N. Sarkaria, Jaime I. Davila, Lorenzo Tofani, Ilaria Battisti, Giorgio Arrigoni, Li Ying, Cheng Zhang, Hu Li, Alexander Meves, Martin E. Fernandez-Zapico, Barbara Stecca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8032a3b6cd4b40e6a08730d54aaaf9c7
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spelling	oai:doaj.org-article:8032a3b6cd4b40e6a08730d54aaaf9c72021-12-02T14:41:13ZST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL10.1038/s41467-020-19575-22041-1723https://doaj.org/article/8032a3b6cd4b40e6a08730d54aaaf9c72020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19575-2https://doaj.org/toc/2041-1723Understanding the molecular events controlling melanoma progression are necessary to find improved therapeutics. Here, the authors report oncogenic SOX2-GLI1 transcriptional complex to drive melanoma invasion through the induction of the sialyltransferase ST3GAL1, and report ST3GAL1-AXL axis as driver of melanoma metastasis.Silvia PietrobonoGiulia AnichiniCesare SalaFabrizio ManettiLuciana L. AlmadaSara PepeRyan M. CarrBrooke D. ParadiseJann N. SarkariaJaime I. DavilaLorenzo TofaniIlaria BattistiGiorgio ArrigoniLi YingCheng ZhangHu LiAlexander MevesMartin E. Fernandez-ZapicoBarbara SteccaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Silvia Pietrobono Giulia Anichini Cesare Sala Fabrizio Manetti Luciana L. Almada Sara Pepe Ryan M. Carr Brooke D. Paradise Jann N. Sarkaria Jaime I. Davila Lorenzo Tofani Ilaria Battisti Giorgio Arrigoni Li Ying Cheng Zhang Hu Li Alexander Meves Martin E. Fernandez-Zapico Barbara Stecca ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
description	Understanding the molecular events controlling melanoma progression are necessary to find improved therapeutics. Here, the authors report oncogenic SOX2-GLI1 transcriptional complex to drive melanoma invasion through the induction of the sialyltransferase ST3GAL1, and report ST3GAL1-AXL axis as driver of melanoma metastasis.
format	article
author	Silvia Pietrobono Giulia Anichini Cesare Sala Fabrizio Manetti Luciana L. Almada Sara Pepe Ryan M. Carr Brooke D. Paradise Jann N. Sarkaria Jaime I. Davila Lorenzo Tofani Ilaria Battisti Giorgio Arrigoni Li Ying Cheng Zhang Hu Li Alexander Meves Martin E. Fernandez-Zapico Barbara Stecca
author_facet	Silvia Pietrobono Giulia Anichini Cesare Sala Fabrizio Manetti Luciana L. Almada Sara Pepe Ryan M. Carr Brooke D. Paradise Jann N. Sarkaria Jaime I. Davila Lorenzo Tofani Ilaria Battisti Giorgio Arrigoni Li Ying Cheng Zhang Hu Li Alexander Meves Martin E. Fernandez-Zapico Barbara Stecca
author_sort	Silvia Pietrobono
title	ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
title_short	ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
title_full	ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
title_fullStr	ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
title_full_unstemmed	ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
title_sort	st3gal1 is a target of the sox2-gli1 transcriptional complex and promotes melanoma metastasis through axl
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8032a3b6cd4b40e6a08730d54aaaf9c7
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ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL

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