LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events

Guangqin Ran, Xiaofan Zhu, Yan Qin Department of Obstetrics and Gynecology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 401147, People’s Republic of ChinaCorrespondence: Yan QinDepartment of Obstetrics and Gynecology, Chongqing General Hospital, University of Ch...

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Autores principales:	Ran G, Zhu X, Qin Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	gestational diabetes mellitus sox2ot adverse events Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/80332be0cebd4e118a9a21dcbfd4d8c2
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spelling	oai:doaj.org-article:80332be0cebd4e118a9a21dcbfd4d8c22021-12-02T17:19:47ZLncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events1178-7007https://doaj.org/article/80332be0cebd4e118a9a21dcbfd4d8c22021-09-01T00:00:00Zhttps://www.dovepress.com/lncrna-sox2ot-is-upregulated-in-gestational-diabetes-mellitus-gdm-and--peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Guangqin Ran, Xiaofan Zhu, Yan Qin Department of Obstetrics and Gynecology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 401147, People’s Republic of ChinaCorrespondence: Yan QinDepartment of Obstetrics and Gynecology, Chongqing General Hospital, University of Chinese Academy of Sciences, No. 118, Xingguang Avenue, Liangjiang New Area, Chongqing, 401147, People’s Republic of ChinaTel +86 23-63390545Email yanqinchongqing@163.comPurpose: LncRNA SOX2OT plays protective roles in high glucose-induced injuries, suggesting its potential involvement in diabetes. Therefore, we analyzed the role of SOX2OT in gestational diabetes mellitus (GDM).Methods: A total of 216 pregnant women with a gestational age of about 2 months were enrolled in this study. The 216 pregnant women were monitored until delivery to record the occurrence of GDM. Adverse events, including miscarriage, premature delivery, intrauterine distress, intrauterine death, intrauterine infection, fetal malformation, macrosomia, and hypertension, were recorded.Results: Two hundred sixteen pregnant women were divided into high and low SOX2OT level groups (n=108), with the median plasma SOX2OT level on the day of admission as the cutoff value. It was observed that the incidence of GDM was higher in the high SOX2OT level group (40/108) than in the low SOX2OT level group (12/108). Moreover, the SOX2OT expression level was higher in GDM patients than in non-GDM participants, and ROC curve analysis showed that plasma SOX2OT levels on the day of admission could separate potential GDM patients from the rest participants. Importantly, higher incidences of miscarriage, premature delivery, intrauterine distress, intrauterine death, intrauterine infection, fetal malformation, macrosomia, and hypertension were observed in the high SOX2OT group compared to the low SOX2OT group.Conclusion: SOX2OT is highly expressed in GDM and is closely correlated with multiple adverse events.Keywords: gestational diabetes mellitus, SOX2OT, adverse eventsRan GZhu XQin YDove Medical Pressarticlegestational diabetes mellitussox2otadverse eventsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3989-3995 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gestational diabetes mellitus sox2ot adverse events Specialties of internal medicine RC581-951
spellingShingle	gestational diabetes mellitus sox2ot adverse events Specialties of internal medicine RC581-951 Ran G Zhu X Qin Y LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events
description	Guangqin Ran, Xiaofan Zhu, Yan Qin Department of Obstetrics and Gynecology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 401147, People’s Republic of ChinaCorrespondence: Yan QinDepartment of Obstetrics and Gynecology, Chongqing General Hospital, University of Chinese Academy of Sciences, No. 118, Xingguang Avenue, Liangjiang New Area, Chongqing, 401147, People’s Republic of ChinaTel +86 23-63390545Email yanqinchongqing@163.comPurpose: LncRNA SOX2OT plays protective roles in high glucose-induced injuries, suggesting its potential involvement in diabetes. Therefore, we analyzed the role of SOX2OT in gestational diabetes mellitus (GDM).Methods: A total of 216 pregnant women with a gestational age of about 2 months were enrolled in this study. The 216 pregnant women were monitored until delivery to record the occurrence of GDM. Adverse events, including miscarriage, premature delivery, intrauterine distress, intrauterine death, intrauterine infection, fetal malformation, macrosomia, and hypertension, were recorded.Results: Two hundred sixteen pregnant women were divided into high and low SOX2OT level groups (n=108), with the median plasma SOX2OT level on the day of admission as the cutoff value. It was observed that the incidence of GDM was higher in the high SOX2OT level group (40/108) than in the low SOX2OT level group (12/108). Moreover, the SOX2OT expression level was higher in GDM patients than in non-GDM participants, and ROC curve analysis showed that plasma SOX2OT levels on the day of admission could separate potential GDM patients from the rest participants. Importantly, higher incidences of miscarriage, premature delivery, intrauterine distress, intrauterine death, intrauterine infection, fetal malformation, macrosomia, and hypertension were observed in the high SOX2OT group compared to the low SOX2OT group.Conclusion: SOX2OT is highly expressed in GDM and is closely correlated with multiple adverse events.Keywords: gestational diabetes mellitus, SOX2OT, adverse events
format	article
author	Ran G Zhu X Qin Y
author_facet	Ran G Zhu X Qin Y
author_sort	Ran G
title	LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events
title_short	LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events
title_full	LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events
title_fullStr	LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events
title_full_unstemmed	LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events
title_sort	lncrna sox2ot is upregulated in gestational diabetes mellitus (gdm) and correlated with multiple adverse events
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/80332be0cebd4e118a9a21dcbfd4d8c2
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LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events

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