Variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach

Abstract Diabetes mellitus type 1 occurs when β‐cells in the pancreas are destroyed by the immune system. As a result, the pancreas cannot produce adequate insulin, and the glucose enters the cells to produce energy. To elevate the glycaemic concentration, sufficient amount of insulin should be take...

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Autor principal:	Mohamadreza Homayounzade
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/80338c9bb302403b9576206566c9257d
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spelling	oai:doaj.org-article:80338c9bb302403b9576206566c9257d2021-11-05T12:10:49ZVariable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach1751-88571751-884910.1049/syb2.12032https://doaj.org/article/80338c9bb302403b9576206566c9257d2021-12-01T00:00:00Zhttps://doi.org/10.1049/syb2.12032https://doaj.org/toc/1751-8849https://doaj.org/toc/1751-8857Abstract Diabetes mellitus type 1 occurs when β‐cells in the pancreas are destroyed by the immune system. As a result, the pancreas cannot produce adequate insulin, and the glucose enters the cells to produce energy. To elevate the glycaemic concentration, sufficient amount of insulin should be taken orally or injected into the human body. Artificial pancreas is a device that automatically regulates the level of body insulin by injecting the requisite amount of insulin into the human body. A finite‐time robust feedback controller based on the Extended Bergman Minimal Model is designed here. The controller is designed utilizing the backstepping approach and is robust against the unknown external disturbance and parametric uncertainties. The stability of the system is proved using the Lyapunov theorem. The controller is exponentially stable and hence provides the finite‐time convergence of the blood glucose concentration to its desired magnitude. The effectiveness of the proposed control method is shown through simulation in MATLAB/Simulink environment via comparisons with previous studies.Mohamadreza HomayounzadeWileyarticleBiology (General)QH301-705.5ENIET Systems Biology, Vol 15, Iss 6, Pp 173-183 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mohamadreza Homayounzade Variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach
description	Abstract Diabetes mellitus type 1 occurs when β‐cells in the pancreas are destroyed by the immune system. As a result, the pancreas cannot produce adequate insulin, and the glucose enters the cells to produce energy. To elevate the glycaemic concentration, sufficient amount of insulin should be taken orally or injected into the human body. Artificial pancreas is a device that automatically regulates the level of body insulin by injecting the requisite amount of insulin into the human body. A finite‐time robust feedback controller based on the Extended Bergman Minimal Model is designed here. The controller is designed utilizing the backstepping approach and is robust against the unknown external disturbance and parametric uncertainties. The stability of the system is proved using the Lyapunov theorem. The controller is exponentially stable and hence provides the finite‐time convergence of the blood glucose concentration to its desired magnitude. The effectiveness of the proposed control method is shown through simulation in MATLAB/Simulink environment via comparisons with previous studies.
format	article
author	Mohamadreza Homayounzade
author_facet	Mohamadreza Homayounzade
author_sort	Mohamadreza Homayounzade
title	Variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach
title_short	Variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach
title_full	Variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach
title_fullStr	Variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach
title_full_unstemmed	Variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach
title_sort	variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: a backstepping approach
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/80338c9bb302403b9576206566c9257d
work_keys_str_mv	AT mohamadrezahomayounzade variablestructurerobustcontrollerdesignforbloodglucoseregulationfortype1diabeticpatientsabacksteppingapproach
_version_	1718444299272585216

Variable structure robust controller design for blood glucose regulation for type 1 diabetic patients: A backstepping approach

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