New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that...
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| Main Authors: | , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2014
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| Subjects: | |
| Online Access: | https://doaj.org/article/8034bd37e091475db8918b2804eddb9a |
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| Summary: | ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings. |
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