New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection

ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Vinayaka R. Prasad, Michael I. Bukrinsky
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Acceso en línea:https://doaj.org/article/8034bd37e091475db8918b2804eddb9a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:8034bd37e091475db8918b2804eddb9a
record_format dspace
spelling oai:doaj.org-article:8034bd37e091475db8918b2804eddb9a2021-11-15T15:47:39ZNew Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection10.1128/mBio.01396-142150-7511https://doaj.org/article/8034bd37e091475db8918b2804eddb9a2014-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01396-14https://doaj.org/toc/2150-7511ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings.Vinayaka R. PrasadMichael I. BukrinskyAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 3 (2014)
institution DOAJ
collection DOAJ
language EN
topic Microbiology
QR1-502
spellingShingle Microbiology
QR1-502
Vinayaka R. Prasad
Michael I. Bukrinsky
New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
description ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings.
format article
author Vinayaka R. Prasad
Michael I. Bukrinsky
author_facet Vinayaka R. Prasad
Michael I. Bukrinsky
author_sort Vinayaka R. Prasad
title New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_short New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_full New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_fullStr New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_full_unstemmed New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_sort new clues to understanding hiv nonprogressors: low cholesterol blocks hiv <italic toggle="yes">trans</italic> infection
publisher American Society for Microbiology
publishDate 2014
url https://doaj.org/article/8034bd37e091475db8918b2804eddb9a
work_keys_str_mv AT vinayakarprasad newcluestounderstandinghivnonprogressorslowcholesterolblockshivitalictoggleyestransitalicinfection
AT michaelibukrinsky newcluestounderstandinghivnonprogressorslowcholesterolblockshivitalictoggleyestransitalicinfection
_version_ 1718427528027176960