New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that...
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American Society for Microbiology
2014
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oai:doaj.org-article:8034bd37e091475db8918b2804eddb9a2021-11-15T15:47:39ZNew Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection10.1128/mBio.01396-142150-7511https://doaj.org/article/8034bd37e091475db8918b2804eddb9a2014-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01396-14https://doaj.org/toc/2150-7511ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings.Vinayaka R. PrasadMichael I. BukrinskyAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 3 (2014) |
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Microbiology QR1-502 Vinayaka R. Prasad Michael I. Bukrinsky New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
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ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings. |
format |
article |
author |
Vinayaka R. Prasad Michael I. Bukrinsky |
author_facet |
Vinayaka R. Prasad Michael I. Bukrinsky |
author_sort |
Vinayaka R. Prasad |
title |
New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
title_short |
New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
title_full |
New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
title_fullStr |
New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
title_full_unstemmed |
New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection |
title_sort |
new clues to understanding hiv nonprogressors: low cholesterol blocks hiv <italic toggle="yes">trans</italic> infection |
publisher |
American Society for Microbiology |
publishDate |
2014 |
url |
https://doaj.org/article/8034bd37e091475db8918b2804eddb9a |
work_keys_str_mv |
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_version_ |
1718427528027176960 |