New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection

ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that...

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Main Authors:	Vinayaka R. Prasad, Michael I. Bukrinsky
Format:	article
Language:	EN
Published:	American Society for Microbiology 2014
Subjects:	Microbiology QR1-502
Online Access:	https://doaj.org/article/8034bd37e091475db8918b2804eddb9a
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id	oai:doaj.org-article:8034bd37e091475db8918b2804eddb9a
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spelling	oai:doaj.org-article:8034bd37e091475db8918b2804eddb9a2021-11-15T15:47:39ZNew Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection10.1128/mBio.01396-142150-7511https://doaj.org/article/8034bd37e091475db8918b2804eddb9a2014-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01396-14https://doaj.org/toc/2150-7511ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings.Vinayaka R. PrasadMichael I. BukrinskyAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 3 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Vinayaka R. Prasad Michael I. Bukrinsky New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
description	ABSTRACT A small percentage of HIV-infected subjects (2 to 15%) are able to control disease progression for many years without antiretroviral therapy. Years of intense studies of virologic and immunologic mechanisms of disease control in such individuals yielded a number of possible host genes that could be responsible for the preservation of immune functions, from immune surveillance genes, chemokines, or their receptors to anti-HIV restriction factors. A recent mBio paper by Rappocciolo et al. (G. Rappocciolo, M. Jais, P. Piazza, T. A. Reinhart, S. J. Berendam, L. Garcia-Exposito, P. Gupta, and C. R. Rinaldo, mBio 5:e01031-13, 2014) describes another potential factor controlling disease progression: cholesterol levels in antigen-presenting cells. In this commentary, we provide a brief background of the role of cholesterol in HIV infection, discuss the results of the study by Rappocciolo et al., and present the implications of their findings.
format	article
author	Vinayaka R. Prasad Michael I. Bukrinsky
author_facet	Vinayaka R. Prasad Michael I. Bukrinsky
author_sort	Vinayaka R. Prasad
title	New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_short	New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_full	New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_fullStr	New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_full_unstemmed	New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection
title_sort	new clues to understanding hiv nonprogressors: low cholesterol blocks hiv <italic toggle="yes">trans</italic> infection
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/8034bd37e091475db8918b2804eddb9a
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New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV <italic toggle="yes">Trans</italic> Infection

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