Reduced Rank Regression-Derived Dietary Patterns Related to the Fatty Liver Index and Associations with Type 2 Diabetes Mellitus among Ghanaian Populations under Transition: The RODAM Study

The Fatty Liver Index (FLI) is a proxy for the steatotic component of non-alcoholic fatty liver disease (NAFLD). For sub-Saharan African populations, the contribution of dietary factors to the development of NAFLD in the etiology of type 2 diabetes mellitus (T2DM) remains to be clarified. We identif...

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Autores principales: Tracy Bonsu Osei, Anne-Marieke van Dijk, Sjoerd Dingerink, Felix Patience Chilunga, Erik Beune, Karlijn Anna Catharina Meeks, Silver Bahendeka, Matthias Bernd Schulze, Charles Agyemang, Mary Nicolaou, Adriaan Georgius Holleboom, Ina Danquah
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:8034d776d2c043b8bebfc974d9b4e51b2021-11-25T18:33:08ZReduced Rank Regression-Derived Dietary Patterns Related to the Fatty Liver Index and Associations with Type 2 Diabetes Mellitus among Ghanaian Populations under Transition: The RODAM Study10.3390/nu131136792072-6643https://doaj.org/article/8034d776d2c043b8bebfc974d9b4e51b2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3679https://doaj.org/toc/2072-6643The Fatty Liver Index (FLI) is a proxy for the steatotic component of non-alcoholic fatty liver disease (NAFLD). For sub-Saharan African populations, the contribution of dietary factors to the development of NAFLD in the etiology of type 2 diabetes mellitus (T2DM) remains to be clarified. We identified sex-specific dietary patterns (DPs) related to the FLI using reduced ranked regression (RRR) and evaluated the associations of these DPs with T2DM. This analysis used data from the RODAM, a multi-center cross-sectional study of Ghanaian populations living in Ghana and Europe. The daily intake frequencies of 30 food groups served as the predictor variables, while the FLI was the response variable. The odds ratios and 95% confidence intervals for T2DM were calculated per one standard deviation increase in the DP score using logistic regression. In males, the DP score explained 9.9% of the variation in their food intake and 16.0% of the variation in the FLI. This DP was characterized by high intakes of poultry, whole-grain cereals, coffee and tea, condiments, and potatoes, and the chance of T2DM was 45% higher per 1 DP score-SD (Model 2). Our results indicate that the intake of modernized foods was associated with proxies of NAFLD, possibly underlying the metabolic pathways to developing T2DM.Tracy Bonsu OseiAnne-Marieke van DijkSjoerd DingerinkFelix Patience ChilungaErik BeuneKarlijn Anna Catharina MeeksSilver BahendekaMatthias Bernd SchulzeCharles AgyemangMary NicolaouAdriaan Georgius HolleboomIna DanquahMDPI AGarticledietary patternreduced rank regressionfatty liver indextype 2 diabetes mellitusnon-alcoholic fatty liver diseaseNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3679, p 3679 (2021)
institution DOAJ
collection DOAJ
language EN
topic dietary pattern
reduced rank regression
fatty liver index
type 2 diabetes mellitus
non-alcoholic fatty liver disease
Nutrition. Foods and food supply
TX341-641
spellingShingle dietary pattern
reduced rank regression
fatty liver index
type 2 diabetes mellitus
non-alcoholic fatty liver disease
Nutrition. Foods and food supply
TX341-641
Tracy Bonsu Osei
Anne-Marieke van Dijk
Sjoerd Dingerink
Felix Patience Chilunga
Erik Beune
Karlijn Anna Catharina Meeks
Silver Bahendeka
Matthias Bernd Schulze
Charles Agyemang
Mary Nicolaou
Adriaan Georgius Holleboom
Ina Danquah
Reduced Rank Regression-Derived Dietary Patterns Related to the Fatty Liver Index and Associations with Type 2 Diabetes Mellitus among Ghanaian Populations under Transition: The RODAM Study
description The Fatty Liver Index (FLI) is a proxy for the steatotic component of non-alcoholic fatty liver disease (NAFLD). For sub-Saharan African populations, the contribution of dietary factors to the development of NAFLD in the etiology of type 2 diabetes mellitus (T2DM) remains to be clarified. We identified sex-specific dietary patterns (DPs) related to the FLI using reduced ranked regression (RRR) and evaluated the associations of these DPs with T2DM. This analysis used data from the RODAM, a multi-center cross-sectional study of Ghanaian populations living in Ghana and Europe. The daily intake frequencies of 30 food groups served as the predictor variables, while the FLI was the response variable. The odds ratios and 95% confidence intervals for T2DM were calculated per one standard deviation increase in the DP score using logistic regression. In males, the DP score explained 9.9% of the variation in their food intake and 16.0% of the variation in the FLI. This DP was characterized by high intakes of poultry, whole-grain cereals, coffee and tea, condiments, and potatoes, and the chance of T2DM was 45% higher per 1 DP score-SD (Model 2). Our results indicate that the intake of modernized foods was associated with proxies of NAFLD, possibly underlying the metabolic pathways to developing T2DM.
format article
author Tracy Bonsu Osei
Anne-Marieke van Dijk
Sjoerd Dingerink
Felix Patience Chilunga
Erik Beune
Karlijn Anna Catharina Meeks
Silver Bahendeka
Matthias Bernd Schulze
Charles Agyemang
Mary Nicolaou
Adriaan Georgius Holleboom
Ina Danquah
author_facet Tracy Bonsu Osei
Anne-Marieke van Dijk
Sjoerd Dingerink
Felix Patience Chilunga
Erik Beune
Karlijn Anna Catharina Meeks
Silver Bahendeka
Matthias Bernd Schulze
Charles Agyemang
Mary Nicolaou
Adriaan Georgius Holleboom
Ina Danquah
author_sort Tracy Bonsu Osei
title Reduced Rank Regression-Derived Dietary Patterns Related to the Fatty Liver Index and Associations with Type 2 Diabetes Mellitus among Ghanaian Populations under Transition: The RODAM Study
title_short Reduced Rank Regression-Derived Dietary Patterns Related to the Fatty Liver Index and Associations with Type 2 Diabetes Mellitus among Ghanaian Populations under Transition: The RODAM Study
title_full Reduced Rank Regression-Derived Dietary Patterns Related to the Fatty Liver Index and Associations with Type 2 Diabetes Mellitus among Ghanaian Populations under Transition: The RODAM Study
title_fullStr Reduced Rank Regression-Derived Dietary Patterns Related to the Fatty Liver Index and Associations with Type 2 Diabetes Mellitus among Ghanaian Populations under Transition: The RODAM Study
title_full_unstemmed Reduced Rank Regression-Derived Dietary Patterns Related to the Fatty Liver Index and Associations with Type 2 Diabetes Mellitus among Ghanaian Populations under Transition: The RODAM Study
title_sort reduced rank regression-derived dietary patterns related to the fatty liver index and associations with type 2 diabetes mellitus among ghanaian populations under transition: the rodam study
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/8034d776d2c043b8bebfc974d9b4e51b
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