Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure

RNA sensors—Riboswitches—respond to the binding of small molecules ligands through structure modification. Here the authors identify synthetic small molecules that bind and regulate the activity of PreQ1 Riboswitches despite having no obvious chemical similarity to the cognate ligand.

Guardado en:

Detalles Bibliográficos
Autores principales:	Colleen M. Connelly, Tomoyuki Numata, Robert E. Boer, Michelle H. Moon, Ranu S. Sinniah, Joseph J. Barchi, Adrian R. Ferré-D’Amaré, John S. Schneekloth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8034f2bb7b9a4f67ba723ce0a274264d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8034f2bb7b9a4f67ba723ce0a274264d
record_format	dspace
spelling	oai:doaj.org-article:8034f2bb7b9a4f67ba723ce0a274264d2021-12-02T15:35:09ZSynthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure10.1038/s41467-019-09493-32041-1723https://doaj.org/article/8034f2bb7b9a4f67ba723ce0a274264d2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09493-3https://doaj.org/toc/2041-1723RNA sensors—Riboswitches—respond to the binding of small molecules ligands through structure modification. Here the authors identify synthetic small molecules that bind and regulate the activity of PreQ1 Riboswitches despite having no obvious chemical similarity to the cognate ligand.Colleen M. ConnellyTomoyuki NumataRobert E. BoerMichelle H. MoonRanu S. SinniahJoseph J. BarchiAdrian R. Ferré-D’AmaréJohn S. SchneeklothNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Colleen M. Connelly Tomoyuki Numata Robert E. Boer Michelle H. Moon Ranu S. Sinniah Joseph J. Barchi Adrian R. Ferré-D’Amaré John S. Schneekloth Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
description	RNA sensors—Riboswitches—respond to the binding of small molecules ligands through structure modification. Here the authors identify synthetic small molecules that bind and regulate the activity of PreQ1 Riboswitches despite having no obvious chemical similarity to the cognate ligand.
format	article
author	Colleen M. Connelly Tomoyuki Numata Robert E. Boer Michelle H. Moon Ranu S. Sinniah Joseph J. Barchi Adrian R. Ferré-D’Amaré John S. Schneekloth
author_facet	Colleen M. Connelly Tomoyuki Numata Robert E. Boer Michelle H. Moon Ranu S. Sinniah Joseph J. Barchi Adrian R. Ferré-D’Amaré John S. Schneekloth
author_sort	Colleen M. Connelly
title	Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
title_short	Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
title_full	Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
title_fullStr	Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
title_full_unstemmed	Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure
title_sort	synthetic ligands for preq1 riboswitches provide structural and mechanistic insights into targeting rna tertiary structure
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8034f2bb7b9a4f67ba723ce0a274264d
work_keys_str_mv	AT colleenmconnelly syntheticligandsforpreq1riboswitchesprovidestructuralandmechanisticinsightsintotargetingrnatertiarystructure AT tomoyukinumata syntheticligandsforpreq1riboswitchesprovidestructuralandmechanisticinsightsintotargetingrnatertiarystructure AT roberteboer syntheticligandsforpreq1riboswitchesprovidestructuralandmechanisticinsightsintotargetingrnatertiarystructure AT michellehmoon syntheticligandsforpreq1riboswitchesprovidestructuralandmechanisticinsightsintotargetingrnatertiarystructure AT ranussinniah syntheticligandsforpreq1riboswitchesprovidestructuralandmechanisticinsightsintotargetingrnatertiarystructure AT josephjbarchi syntheticligandsforpreq1riboswitchesprovidestructuralandmechanisticinsightsintotargetingrnatertiarystructure AT adrianrferredamare syntheticligandsforpreq1riboswitchesprovidestructuralandmechanisticinsightsintotargetingrnatertiarystructure AT johnsschneekloth syntheticligandsforpreq1riboswitchesprovidestructuralandmechanisticinsightsintotargetingrnatertiarystructure
_version_	1718386665618145280

Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure

Ejemplares similares