3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.

3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.

3,3'-Diindolylmethane (DIM), one of the active products derived from Brassica plants, is a promising antitumor agent. The present study indicated that DIM significantly induced apoptosis in U937 human leukemia cells in dose- and time-dependent manners. These events were also noted in other huma...

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Autores principales: Ning Gao, Senping Cheng, Amit Budhraja, E-Hu Liu, Jieping Chen, Deying Chen, Zailin Yang, Jia Luo, Xianglin Shi, Zhuo Zhang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/803555ab16ed48d28a11a2c400c25cb3
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