Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk

Abstract Retinal vessel phenotype is predictive for cardiovascular outcome. This cross-sectional population-based study aimed to quantify normative data and standard operating procedures for static and dynamic retinal vessel analysis. We analysed central retinal arteriolar (CRAE) and venular (CRVE)...

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Autores principales:	Lukas Streese, Giulia Lona, Jonathan Wagner, Raphael Knaier, Andri Burri, Gilles Nève, Denis Infanger, Walthard Vilser, Arno Schmidt-Trucksäss, Henner Hanssen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/80367234851f418bb1081de22aed442c
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spelling	oai:doaj.org-article:80367234851f418bb1081de22aed442c2021-12-02T16:14:56ZNormative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk10.1038/s41598-021-93617-72045-2322https://doaj.org/article/80367234851f418bb1081de22aed442c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93617-7https://doaj.org/toc/2045-2322Abstract Retinal vessel phenotype is predictive for cardiovascular outcome. This cross-sectional population-based study aimed to quantify normative data and standard operating procedures for static and dynamic retinal vessel analysis. We analysed central retinal arteriolar (CRAE) and venular (CRVE) diameter equivalents, as well as retinal endothelial function, measured by flicker light‐induced maximal arteriolar (aFID) and venular (vFID) dilatation. Measurements were performed in 277 healthy individuals aged 20 to 82 years of the COmPLETE study. The mean range from the youngest compared to the oldest decade was 196 ± 13 to 166 ± 17 µm for CRAE, 220 ± 15 to 199 ± 16 µm for CRVE, 3.74 ± 2.17 to 3.79 ± 2.43% for aFID and 4.64 ± 1.85 to 3.86 ± 1.56% for vFID. Lower CRAE [estimate (95% CI): − 0.52 (− 0.61 to − 0.43)], CRVE [− 0.33 (− 0.43 to − 0.24)] and vFID [− 0.01 (− 0.26 to − 0.00)], but not aFID, were significantly associated with older age. Interestingly, higher blood pressure was associated with narrower CRAE [− 0.82 (− 1.00 to − 0.63)] but higher aFID [0.05 (0.03 to 0.07)]. Likewise, narrower CRAE were associated with a higher predicted aFID [− 0.02 (− 0.37 to − 0.01)]. We recommend use of defined standardized operating procedures and cardiovascular risk stratification based on normative data to allow for clinical implementation of retinal vessel analysis in a personalized medicine approach.Lukas StreeseGiulia LonaJonathan WagnerRaphael KnaierAndri BurriGilles NèveDenis InfangerWalthard VilserArno Schmidt-TrucksässHenner HanssenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lukas Streese Giulia Lona Jonathan Wagner Raphael Knaier Andri Burri Gilles Nève Denis Infanger Walthard Vilser Arno Schmidt-Trucksäss Henner Hanssen Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk
description	Abstract Retinal vessel phenotype is predictive for cardiovascular outcome. This cross-sectional population-based study aimed to quantify normative data and standard operating procedures for static and dynamic retinal vessel analysis. We analysed central retinal arteriolar (CRAE) and venular (CRVE) diameter equivalents, as well as retinal endothelial function, measured by flicker light‐induced maximal arteriolar (aFID) and venular (vFID) dilatation. Measurements were performed in 277 healthy individuals aged 20 to 82 years of the COmPLETE study. The mean range from the youngest compared to the oldest decade was 196 ± 13 to 166 ± 17 µm for CRAE, 220 ± 15 to 199 ± 16 µm for CRVE, 3.74 ± 2.17 to 3.79 ± 2.43% for aFID and 4.64 ± 1.85 to 3.86 ± 1.56% for vFID. Lower CRAE [estimate (95% CI): − 0.52 (− 0.61 to − 0.43)], CRVE [− 0.33 (− 0.43 to − 0.24)] and vFID [− 0.01 (− 0.26 to − 0.00)], but not aFID, were significantly associated with older age. Interestingly, higher blood pressure was associated with narrower CRAE [− 0.82 (− 1.00 to − 0.63)] but higher aFID [0.05 (0.03 to 0.07)]. Likewise, narrower CRAE were associated with a higher predicted aFID [− 0.02 (− 0.37 to − 0.01)]. We recommend use of defined standardized operating procedures and cardiovascular risk stratification based on normative data to allow for clinical implementation of retinal vessel analysis in a personalized medicine approach.
format	article
author	Lukas Streese Giulia Lona Jonathan Wagner Raphael Knaier Andri Burri Gilles Nève Denis Infanger Walthard Vilser Arno Schmidt-Trucksäss Henner Hanssen
author_facet	Lukas Streese Giulia Lona Jonathan Wagner Raphael Knaier Andri Burri Gilles Nève Denis Infanger Walthard Vilser Arno Schmidt-Trucksäss Henner Hanssen
author_sort	Lukas Streese
title	Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk
title_short	Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk
title_full	Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk
title_fullStr	Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk
title_full_unstemmed	Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk
title_sort	normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/80367234851f418bb1081de22aed442c
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_version_	1718384300270813184

Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk

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