Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer

BACKGROUND AND OBJECTIVE: Many deaths from cancer are due to metastases, a process which involves the epithelial-mesenchymal transition (EMT). On the other hand, regular exercise plays an important role in inhibiting the progression of breast cancer. Therefore, the purpose of this study was to inves...

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Autores principales:	S Gholamian, SR Attarzadeh Hoseini, A Rashidlamir, H Aghaalinejad
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	breast cancer mesenchymal biomarkers interval training tumor. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8036d5e7b82f4e6197258cebb76c5956
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spelling	oai:doaj.org-article:8036d5e7b82f4e6197258cebb76c59562021-11-09T10:15:54ZEffect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer1561-41072251-7170https://doaj.org/article/8036d5e7b82f4e6197258cebb76c59562020-03-01T00:00:00Zhttp://jbums.org/article-1-8470-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Many deaths from cancer are due to metastases, a process which involves the epithelial-mesenchymal transition (EMT). On the other hand, regular exercise plays an important role in inhibiting the progression of breast cancer. Therefore, the purpose of this study was to investigate the influence aerobic interval training on expression of mesenchymal biomarkers, and tumor volume in mice with breast cancer. METHODS: In this experimental study, Thirty-two female BALB/c mice, aged 3-5 weeks (17±1g) were used. The mice were allocated to four groups: Exercise Tumor, Exercise (aerobic Interval training was performed six weeks (40 minutes) before and four weeks (30 minutes) after the induction of carcinoma with active recovery), Rest Tumor, Rest (Control- without exercise), Rest, Tumor, Exercise, (four weeks after the induction of carcinoma) and Exercise, Tumor, Rest (six weeks before the induction of carcinoma). The real-time PCR method was used to evaluate the expression of Vimentin and Twist. FINDINGS: The results of present study demonstrated that tumor tissue Vimentin expression in the Exercise Tumor Exercise (223.0±0.073) group decreased significantly (p= 0.0001), Also, the expression of Twist gene was significantly reduced in Exercise Tumor Exercise group (0.24±0.227) compared to control group (p=0.008). A significant decrease in tumor volume was observed in both RTE and ETE groups compared to the control group (RTR) (p = 0.0001). CONCLUSION: Based on the results of this study, a period of interval aerobic training can decrease the expression of Vimentin، Twist and decrease the tumor volume ratio.S GholamianSR Attarzadeh HoseiniA RashidlamirH AghaalinejadBabol University of Medical Sciencesarticlebreast cancermesenchymal biomarkersinterval trainingtumor.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 24-30 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	breast cancer mesenchymal biomarkers interval training tumor. Medicine R Medicine (General) R5-920
spellingShingle	breast cancer mesenchymal biomarkers interval training tumor. Medicine R Medicine (General) R5-920 S Gholamian SR Attarzadeh Hoseini A Rashidlamir H Aghaalinejad Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer
description	BACKGROUND AND OBJECTIVE: Many deaths from cancer are due to metastases, a process which involves the epithelial-mesenchymal transition (EMT). On the other hand, regular exercise plays an important role in inhibiting the progression of breast cancer. Therefore, the purpose of this study was to investigate the influence aerobic interval training on expression of mesenchymal biomarkers, and tumor volume in mice with breast cancer. METHODS: In this experimental study, Thirty-two female BALB/c mice, aged 3-5 weeks (17±1g) were used. The mice were allocated to four groups: Exercise Tumor, Exercise (aerobic Interval training was performed six weeks (40 minutes) before and four weeks (30 minutes) after the induction of carcinoma with active recovery), Rest Tumor, Rest (Control- without exercise), Rest, Tumor, Exercise, (four weeks after the induction of carcinoma) and Exercise, Tumor, Rest (six weeks before the induction of carcinoma). The real-time PCR method was used to evaluate the expression of Vimentin and Twist. FINDINGS: The results of present study demonstrated that tumor tissue Vimentin expression in the Exercise Tumor Exercise (223.0±0.073) group decreased significantly (p= 0.0001), Also, the expression of Twist gene was significantly reduced in Exercise Tumor Exercise group (0.24±0.227) compared to control group (p=0.008). A significant decrease in tumor volume was observed in both RTE and ETE groups compared to the control group (RTR) (p = 0.0001). CONCLUSION: Based on the results of this study, a period of interval aerobic training can decrease the expression of Vimentin، Twist and decrease the tumor volume ratio.
format	article
author	S Gholamian SR Attarzadeh Hoseini A Rashidlamir H Aghaalinejad
author_facet	S Gholamian SR Attarzadeh Hoseini A Rashidlamir H Aghaalinejad
author_sort	S Gholamian
title	Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer
title_short	Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer
title_full	Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer
title_fullStr	Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer
title_full_unstemmed	Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer
title_sort	effect of aerobic interval training on expression of twist and vimentin and the rate of tumor volume in mice with breast cancer
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/8036d5e7b82f4e6197258cebb76c5956
work_keys_str_mv	AT sgholamian effectofaerobicintervaltrainingonexpressionoftwistandvimentinandtherateoftumorvolumeinmicewithbreastcancer AT srattarzadehhoseini effectofaerobicintervaltrainingonexpressionoftwistandvimentinandtherateoftumorvolumeinmicewithbreastcancer AT arashidlamir effectofaerobicintervaltrainingonexpressionoftwistandvimentinandtherateoftumorvolumeinmicewithbreastcancer AT haghaalinejad effectofaerobicintervaltrainingonexpressionoftwistandvimentinandtherateoftumorvolumeinmicewithbreastcancer
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Effect of Aerobic Interval Training on Expression of Twist and Vimentin and the Rate of Tumor Volume in Mice with Breast Cancer

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