Multivariate FMRI Signatures of Learning in a Hebb Repetition Paradigm With Tone Sequences

Important information from the environment often arrives to the brain in temporally extended sequences. Language, music, actions, and complex events generally unfold over time. When such informational sequences exceed the limited capacity of working memory, the human brain relies on its ability to a...

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Autores principales:	Corey Loo, Andy C. H. Lee, Bradley R. Buchsbaum
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	working memory learning fMRI representational similarity analysis auditory memory sequence memory Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/80394698bb51427f9cf1c17bf7ad8ba0
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id	oai:doaj.org-article:80394698bb51427f9cf1c17bf7ad8ba0
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spelling	oai:doaj.org-article:80394698bb51427f9cf1c17bf7ad8ba02021-12-01T12:30:31ZMultivariate FMRI Signatures of Learning in a Hebb Repetition Paradigm With Tone Sequences1664-229510.3389/fneur.2021.674275https://doaj.org/article/80394698bb51427f9cf1c17bf7ad8ba02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.674275/fullhttps://doaj.org/toc/1664-2295Important information from the environment often arrives to the brain in temporally extended sequences. Language, music, actions, and complex events generally unfold over time. When such informational sequences exceed the limited capacity of working memory, the human brain relies on its ability to accumulate information in long-term memory over several encounters with a complex stimulus. A longstanding question in psychology and neuroscience is whether the neural structures associated with working memory storage—often viewed as capacity limited and temporary—have any builtin ability to store information across longer temporal delays. According to the classic Hebbian dual memory theory, temporally local “activity traces” underlie immediate perception and working memory, whereas “structural traces” undergird long-term learning. Here we examine whether brain structures known to be involved in working maintenance of auditory sequences, such as area Spt, also show evidence of memory persistence across trials. We used representational similarity analysis (RSA) and the Hebb repetition paradigm with supracapacity tonal sequences to test whether repeated sequences have distinguishable multivoxel activity patterns in the auditory-motor networks of the brain. We found that, indeed, area Spt and other nodes of the auditory dorsal stream show multivoxel patterns for tone sequences that become gradually more distinct with repetition during working memory for supracapacity tone-sequences. The findings suggest that the structures are important for working memory are not “blank slates,” wiped clean from moment to moment, but rather encode information in a way can lead to cross-trial persistence.Corey LooCorey LooAndy C. H. LeeAndy C. H. LeeBradley R. BuchsbaumBradley R. BuchsbaumFrontiers Media S.A.articleworking memorylearningfMRIrepresentational similarity analysisauditory memorysequence memoryNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	working memory learning fMRI representational similarity analysis auditory memory sequence memory Neurology. Diseases of the nervous system RC346-429
spellingShingle	working memory learning fMRI representational similarity analysis auditory memory sequence memory Neurology. Diseases of the nervous system RC346-429 Corey Loo Corey Loo Andy C. H. Lee Andy C. H. Lee Bradley R. Buchsbaum Bradley R. Buchsbaum Multivariate FMRI Signatures of Learning in a Hebb Repetition Paradigm With Tone Sequences
description	Important information from the environment often arrives to the brain in temporally extended sequences. Language, music, actions, and complex events generally unfold over time. When such informational sequences exceed the limited capacity of working memory, the human brain relies on its ability to accumulate information in long-term memory over several encounters with a complex stimulus. A longstanding question in psychology and neuroscience is whether the neural structures associated with working memory storage—often viewed as capacity limited and temporary—have any builtin ability to store information across longer temporal delays. According to the classic Hebbian dual memory theory, temporally local “activity traces” underlie immediate perception and working memory, whereas “structural traces” undergird long-term learning. Here we examine whether brain structures known to be involved in working maintenance of auditory sequences, such as area Spt, also show evidence of memory persistence across trials. We used representational similarity analysis (RSA) and the Hebb repetition paradigm with supracapacity tonal sequences to test whether repeated sequences have distinguishable multivoxel activity patterns in the auditory-motor networks of the brain. We found that, indeed, area Spt and other nodes of the auditory dorsal stream show multivoxel patterns for tone sequences that become gradually more distinct with repetition during working memory for supracapacity tone-sequences. The findings suggest that the structures are important for working memory are not “blank slates,” wiped clean from moment to moment, but rather encode information in a way can lead to cross-trial persistence.
format	article
author	Corey Loo Corey Loo Andy C. H. Lee Andy C. H. Lee Bradley R. Buchsbaum Bradley R. Buchsbaum
author_facet	Corey Loo Corey Loo Andy C. H. Lee Andy C. H. Lee Bradley R. Buchsbaum Bradley R. Buchsbaum
author_sort	Corey Loo
title	Multivariate FMRI Signatures of Learning in a Hebb Repetition Paradigm With Tone Sequences
title_short	Multivariate FMRI Signatures of Learning in a Hebb Repetition Paradigm With Tone Sequences
title_full	Multivariate FMRI Signatures of Learning in a Hebb Repetition Paradigm With Tone Sequences
title_fullStr	Multivariate FMRI Signatures of Learning in a Hebb Repetition Paradigm With Tone Sequences
title_full_unstemmed	Multivariate FMRI Signatures of Learning in a Hebb Repetition Paradigm With Tone Sequences
title_sort	multivariate fmri signatures of learning in a hebb repetition paradigm with tone sequences
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/80394698bb51427f9cf1c17bf7ad8ba0
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Multivariate FMRI Signatures of Learning in a Hebb Repetition Paradigm With Tone Sequences

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