Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells.
Human DICER1 protein cleaves double-stranded RNA into small sizes, a crucial step in production of single-stranded RNAs which are mediating factors of cytoplasmic RNA interference. Here, we clearly demonstrate that human DICER1 protein localizes not only to the cytoplasm but also to the nucleoplasm....
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2011
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oai:doaj.org-article:803b6e1077a941528d8bba48166c136b2021-11-18T06:47:58ZNuclear pore complex protein mediated nuclear localization of dicer protein in human cells.1932-620310.1371/journal.pone.0023385https://doaj.org/article/803b6e1077a941528d8bba48166c136b2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21858095/?tool=EBIhttps://doaj.org/toc/1932-6203Human DICER1 protein cleaves double-stranded RNA into small sizes, a crucial step in production of single-stranded RNAs which are mediating factors of cytoplasmic RNA interference. Here, we clearly demonstrate that human DICER1 protein localizes not only to the cytoplasm but also to the nucleoplasm. We also find that human DICER1 protein associates with the NUP153 protein, one component of the nuclear pore complex. This association is detected predominantly in the cytoplasm but is also clearly distinguishable at the nuclear periphery. Additional characterization of the NUP153-DICER1 association suggests NUP153 plays a crucial role in the nuclear localization of the DICER1 protein.Yoshinari AndoYoshinari AndoYasuhiro TomaruAyako MorinagaAlexander Maxwell BurroughsHideya KawajiAtsutaka KubosakiRyuichiro KimuraMaiko TagataYoko InoHisashi HiranoJoe ChibaHarukazu SuzukiPiero CarninciYoshihide HayashizakiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23385 (2011) |
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| collection |
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| topic |
Medicine R Science Q |
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Medicine R Science Q Yoshinari Ando Yoshinari Ando Yasuhiro Tomaru Ayako Morinaga Alexander Maxwell Burroughs Hideya Kawaji Atsutaka Kubosaki Ryuichiro Kimura Maiko Tagata Yoko Ino Hisashi Hirano Joe Chiba Harukazu Suzuki Piero Carninci Yoshihide Hayashizaki Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. |
| description |
Human DICER1 protein cleaves double-stranded RNA into small sizes, a crucial step in production of single-stranded RNAs which are mediating factors of cytoplasmic RNA interference. Here, we clearly demonstrate that human DICER1 protein localizes not only to the cytoplasm but also to the nucleoplasm. We also find that human DICER1 protein associates with the NUP153 protein, one component of the nuclear pore complex. This association is detected predominantly in the cytoplasm but is also clearly distinguishable at the nuclear periphery. Additional characterization of the NUP153-DICER1 association suggests NUP153 plays a crucial role in the nuclear localization of the DICER1 protein. |
| format |
article |
| author |
Yoshinari Ando Yoshinari Ando Yasuhiro Tomaru Ayako Morinaga Alexander Maxwell Burroughs Hideya Kawaji Atsutaka Kubosaki Ryuichiro Kimura Maiko Tagata Yoko Ino Hisashi Hirano Joe Chiba Harukazu Suzuki Piero Carninci Yoshihide Hayashizaki |
| author_facet |
Yoshinari Ando Yoshinari Ando Yasuhiro Tomaru Ayako Morinaga Alexander Maxwell Burroughs Hideya Kawaji Atsutaka Kubosaki Ryuichiro Kimura Maiko Tagata Yoko Ino Hisashi Hirano Joe Chiba Harukazu Suzuki Piero Carninci Yoshihide Hayashizaki |
| author_sort |
Yoshinari Ando |
| title |
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. |
| title_short |
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. |
| title_full |
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. |
| title_fullStr |
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. |
| title_full_unstemmed |
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. |
| title_sort |
nuclear pore complex protein mediated nuclear localization of dicer protein in human cells. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/803b6e1077a941528d8bba48166c136b |
| work_keys_str_mv |
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| _version_ |
1718424360383938560 |