Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.

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Autores principales:	Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Proccacia, Germano Cecere
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/803ff8b52d0a47a39490fc9e92339e3c
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spelling	oai:doaj.org-article:803ff8b52d0a47a39490fc9e92339e3c2021-12-02T17:30:39ZTranslation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis10.1038/s41467-021-23615-w2041-1723https://doaj.org/article/803ff8b52d0a47a39490fc9e92339e3c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23615-whttps://doaj.org/toc/2041-172322G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.Meetali SinghEric CornesBlaise LiPiergiuseppe QuaratoLoan BourdonFlorent DingliDamarys LoewSimone ProccaciaGermano CecereNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meetali Singh Eric Cornes Blaise Li Piergiuseppe Quarato Loan Bourdon Florent Dingli Damarys Loew Simone Proccacia Germano Cecere Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
description	22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.
format	article
author	Meetali Singh Eric Cornes Blaise Li Piergiuseppe Quarato Loan Bourdon Florent Dingli Damarys Loew Simone Proccacia Germano Cecere
author_facet	Meetali Singh Eric Cornes Blaise Li Piergiuseppe Quarato Loan Bourdon Florent Dingli Damarys Loew Simone Proccacia Germano Cecere
author_sort	Meetali Singh
title	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_short	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_full	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_fullStr	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_full_unstemmed	Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis
title_sort	translation and codon usage regulate argonaute slicer activity to trigger small rna biogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/803ff8b52d0a47a39490fc9e92339e3c
work_keys_str_mv	AT meetalisingh translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT ericcornes translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT blaiseli translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT piergiuseppequarato translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT loanbourdon translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT florentdingli translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT damarysloew translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT simoneproccacia translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis AT germanocecere translationandcodonusageregulateargonautesliceractivitytotriggersmallrnabiogenesis
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Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

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