Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)

Since 2014, several global and national guidelines have been introduced to address the problem of antimicrobial resistance. We conducted a campaign in a tertiary hospital to promote appropriate quinolone use through educational lectures in 2018. The aim of this retrospective study was to evaluate th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Atsushi Uda, Katsumi Shigemura, Koichi Kitagawa, Kayo Osawa, Mari Kusuki, Yonmin Yan, Ikuko Yano, Takayuki Miyara
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antimicrobial stewardship unnecessary antibiotic prescription oral quinolone bacterial resistance educational intervention Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/804391c1496e441c96e9402b35df2e4e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:804391c1496e441c96e9402b35df2e4e
record_format	dspace
spelling	oai:doaj.org-article:804391c1496e441c96e9402b35df2e4e2021-11-25T16:25:13ZEffect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)10.3390/antibiotics101114262079-6382https://doaj.org/article/804391c1496e441c96e9402b35df2e4e2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1426https://doaj.org/toc/2079-6382Since 2014, several global and national guidelines have been introduced to address the problem of antimicrobial resistance. We conducted a campaign in a tertiary hospital to promote appropriate quinolone use through educational lectures in 2018. The aim of this retrospective study was to evaluate the changes in the following: prescription characteristics, trend of oral quinolone use, and antibiotic susceptibility of bacteria from 2013 to 2020. Antimicrobial use was assessed as days of therapy per 1000 patient-days. We found a significant reduction in unnecessary antibiotic prescriptions between December 2013 and December 2020. Significant negative trends were detected in the use of quinolones over 8 years (outpatients, coefficient = −0.15655, <i>p</i> < 0.001; inpatients, coefficient = −0.004825, <i>p</i> = 0.0016). In particular, the monthly mean use of quinolones among outpatients significantly decreased by 11% from 2013 to 2014 (<i>p</i> < 0.05) and reduced further by 31% from 2017 to 2020 (<i>p</i> < 0.001). A significant positive trend was observed in the susceptibility of <i>Pseudomonas aeruginosa</i> to levofloxacin (<i>p</i> < 0.001). These results demonstrate that the use of oral quinolones was further reduced following educational intervention and the bacterial susceptibility improved with optimal quinolone usage compared to that in 2013.Atsushi UdaKatsumi ShigemuraKoichi KitagawaKayo OsawaMari KusukiYonmin YanIkuko YanoTakayuki MiyaraMDPI AGarticleantimicrobial stewardshipunnecessary antibiotic prescriptionoral quinolonebacterial resistanceeducational interventionTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1426, p 1426 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial stewardship unnecessary antibiotic prescription oral quinolone bacterial resistance educational intervention Therapeutics. Pharmacology RM1-950
spellingShingle	antimicrobial stewardship unnecessary antibiotic prescription oral quinolone bacterial resistance educational intervention Therapeutics. Pharmacology RM1-950 Atsushi Uda Katsumi Shigemura Koichi Kitagawa Kayo Osawa Mari Kusuki Yonmin Yan Ikuko Yano Takayuki Miyara Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)
description	Since 2014, several global and national guidelines have been introduced to address the problem of antimicrobial resistance. We conducted a campaign in a tertiary hospital to promote appropriate quinolone use through educational lectures in 2018. The aim of this retrospective study was to evaluate the changes in the following: prescription characteristics, trend of oral quinolone use, and antibiotic susceptibility of bacteria from 2013 to 2020. Antimicrobial use was assessed as days of therapy per 1000 patient-days. We found a significant reduction in unnecessary antibiotic prescriptions between December 2013 and December 2020. Significant negative trends were detected in the use of quinolones over 8 years (outpatients, coefficient = −0.15655, <i>p</i> < 0.001; inpatients, coefficient = −0.004825, <i>p</i> = 0.0016). In particular, the monthly mean use of quinolones among outpatients significantly decreased by 11% from 2013 to 2014 (<i>p</i> < 0.05) and reduced further by 31% from 2017 to 2020 (<i>p</i> < 0.001). A significant positive trend was observed in the susceptibility of <i>Pseudomonas aeruginosa</i> to levofloxacin (<i>p</i> < 0.001). These results demonstrate that the use of oral quinolones was further reduced following educational intervention and the bacterial susceptibility improved with optimal quinolone usage compared to that in 2013.
format	article
author	Atsushi Uda Katsumi Shigemura Koichi Kitagawa Kayo Osawa Mari Kusuki Yonmin Yan Ikuko Yano Takayuki Miyara
author_facet	Atsushi Uda Katsumi Shigemura Koichi Kitagawa Kayo Osawa Mari Kusuki Yonmin Yan Ikuko Yano Takayuki Miyara
author_sort	Atsushi Uda
title	Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)
title_short	Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)
title_full	Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)
title_fullStr	Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)
title_full_unstemmed	Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)
title_sort	effect of antimicrobial stewardship on oral quinolone use and resistance patterns over 8 years (2013–2020)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/804391c1496e441c96e9402b35df2e4e
work_keys_str_mv	AT atsushiuda effectofantimicrobialstewardshiponoralquinoloneuseandresistancepatternsover8years20132020 AT katsumishigemura effectofantimicrobialstewardshiponoralquinoloneuseandresistancepatternsover8years20132020 AT koichikitagawa effectofantimicrobialstewardshiponoralquinoloneuseandresistancepatternsover8years20132020 AT kayoosawa effectofantimicrobialstewardshiponoralquinoloneuseandresistancepatternsover8years20132020 AT marikusuki effectofantimicrobialstewardshiponoralquinoloneuseandresistancepatternsover8years20132020 AT yonminyan effectofantimicrobialstewardshiponoralquinoloneuseandresistancepatternsover8years20132020 AT ikukoyano effectofantimicrobialstewardshiponoralquinoloneuseandresistancepatternsover8years20132020 AT takayukimiyara effectofantimicrobialstewardshiponoralquinoloneuseandresistancepatternsover8years20132020
_version_	1718413209450315776

Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013–2020)

Ejemplares similares