The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression

The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression

Functional characterisation of non-coding risk variants for colorectal cancer is missing. Here the authors conduct a large-scale proteome-wide analysis of disease associated SNPs to characterize allele-specific transcription factor binding landscape in colorectal cancer and identify one functionally...

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Autores principales: Ning Qing Liu, Menno ter Huurne, Luan N. Nguyen, Tianran Peng, Shuang-Yin Wang, James B. Studd, Onkar Joshi, Halit Ongen, Jesper B Bramsen, Jian Yan, Claus L. Andersen, Jussi Taipale, Emmanouil T. Dermitzakis, Richard S. Houlston, Nina C. Hubner, Hendrik G. Stunnenberg
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8044c297681a490eaa5ba7372d960195
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spelling oai:doaj.org-article:8044c297681a490eaa5ba7372d9601952021-12-02T17:06:25ZThe non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression10.1038/ncomms144182041-1723https://doaj.org/article/8044c297681a490eaa5ba7372d9601952017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14418https://doaj.org/toc/2041-1723Functional characterisation of non-coding risk variants for colorectal cancer is missing. Here the authors conduct a large-scale proteome-wide analysis of disease associated SNPs to characterize allele-specific transcription factor binding landscape in colorectal cancer and identify one functionally significant SNP.Ning Qing LiuMenno ter HuurneLuan N. NguyenTianran PengShuang-Yin WangJames B. StuddOnkar JoshiHalit OngenJesper B BramsenJian YanClaus L. AndersenJussi TaipaleEmmanouil T. DermitzakisRichard S. HoulstonNina C. HubnerHendrik G. StunnenbergNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ning Qing Liu
Menno ter Huurne
Luan N. Nguyen
Tianran Peng
Shuang-Yin Wang
James B. Studd
Onkar Joshi
Halit Ongen
Jesper B Bramsen
Jian Yan
Claus L. Andersen
Jussi Taipale
Emmanouil T. Dermitzakis
Richard S. Houlston
Nina C. Hubner
Hendrik G. Stunnenberg
The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
description Functional characterisation of non-coding risk variants for colorectal cancer is missing. Here the authors conduct a large-scale proteome-wide analysis of disease associated SNPs to characterize allele-specific transcription factor binding landscape in colorectal cancer and identify one functionally significant SNP.
format article
author Ning Qing Liu
Menno ter Huurne
Luan N. Nguyen
Tianran Peng
Shuang-Yin Wang
James B. Studd
Onkar Joshi
Halit Ongen
Jesper B Bramsen
Jian Yan
Claus L. Andersen
Jussi Taipale
Emmanouil T. Dermitzakis
Richard S. Houlston
Nina C. Hubner
Hendrik G. Stunnenberg
author_facet Ning Qing Liu
Menno ter Huurne
Luan N. Nguyen
Tianran Peng
Shuang-Yin Wang
James B. Studd
Onkar Joshi
Halit Ongen
Jesper B Bramsen
Jian Yan
Claus L. Andersen
Jussi Taipale
Emmanouil T. Dermitzakis
Richard S. Houlston
Nina C. Hubner
Hendrik G. Stunnenberg
author_sort Ning Qing Liu
title The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
title_short The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
title_full The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
title_fullStr The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
title_full_unstemmed The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
title_sort non-coding variant rs1800734 enhances dclk3 expression through long-range interaction and promotes colorectal cancer progression
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8044c297681a490eaa5ba7372d960195
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