How does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes

Purpose: To describe the clinical symptoms, anatomical location of the injury and different etiologies of one-and-a-half syndrome and its variants. Observations: A small lesion to the brainstem can cause complex syndromes that involve the disfunction of different nuclei and pathways. A 52-year-old m...

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Autores principales:	Gonzalez-Arocha Carla, Rodriguez-Martinez Ana-Catalina, Mohamed-Noriega Jibran
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diplopia Ocular motility Stroke Neuro-ophthalmology One-and-a-half syndrome Brainstem Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8048230fb0b0456f9f5241e105db966e
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spelling	oai:doaj.org-article:8048230fb0b0456f9f5241e105db966e2021-11-04T04:34:35ZHow does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes2451-993610.1016/j.ajoc.2021.101225https://doaj.org/article/8048230fb0b0456f9f5241e105db966e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2451993621002346https://doaj.org/toc/2451-9936Purpose: To describe the clinical symptoms, anatomical location of the injury and different etiologies of one-and-a-half syndrome and its variants. Observations: A small lesion to the brainstem can cause complex syndromes that involve the disfunction of different nuclei and pathways. A 52-year-old man presented with sudden onset of diplopia characterized by horizontal gaze palsy and internuclear ophthalmoplegia (INO). With these clinical characteristics, the patient was diagnosed with the one-and-a-half syndrome. Neuroimaging revealed an acute/subacute ischemic lacunar event in the pontine tegmentum. The one-and-a-half syndrome is described as a horizontal gaze palsy in one direction (damage to the paramedian pontine reticular formation [PPRF] or the VI nerve nucleus) and an internuclear ophthalmoplegia in the other direction (damage to the medial longitudinal fasciculus). Along with the traditional description, the closed anatomical proximity with other nuclei and pathways makes possible the appearance of other more complex syndromes that have been grouped as the one-and-a-half syndrome and its variants. Conclusions and importance: A detailed clinical neuro-ophthalmologic examination, along with a clear understanding of the neuroanatomical pathways, gives clinicians a good diagnostic opportunity to determine the precise location of injuries to the brainstem.Gonzalez-Arocha CarlaRodriguez-Martinez Ana-CatalinaMohamed-Noriega JibranElsevierarticleDiplopiaOcular motilityStrokeNeuro-ophthalmologyOne-and-a-half syndromeBrainstemOphthalmologyRE1-994ENAmerican Journal of Ophthalmology Case Reports, Vol 24, Iss , Pp 101225- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diplopia Ocular motility Stroke Neuro-ophthalmology One-and-a-half syndrome Brainstem Ophthalmology RE1-994
spellingShingle	Diplopia Ocular motility Stroke Neuro-ophthalmology One-and-a-half syndrome Brainstem Ophthalmology RE1-994 Gonzalez-Arocha Carla Rodriguez-Martinez Ana-Catalina Mohamed-Noriega Jibran How does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes
description	Purpose: To describe the clinical symptoms, anatomical location of the injury and different etiologies of one-and-a-half syndrome and its variants. Observations: A small lesion to the brainstem can cause complex syndromes that involve the disfunction of different nuclei and pathways. A 52-year-old man presented with sudden onset of diplopia characterized by horizontal gaze palsy and internuclear ophthalmoplegia (INO). With these clinical characteristics, the patient was diagnosed with the one-and-a-half syndrome. Neuroimaging revealed an acute/subacute ischemic lacunar event in the pontine tegmentum. The one-and-a-half syndrome is described as a horizontal gaze palsy in one direction (damage to the paramedian pontine reticular formation [PPRF] or the VI nerve nucleus) and an internuclear ophthalmoplegia in the other direction (damage to the medial longitudinal fasciculus). Along with the traditional description, the closed anatomical proximity with other nuclei and pathways makes possible the appearance of other more complex syndromes that have been grouped as the one-and-a-half syndrome and its variants. Conclusions and importance: A detailed clinical neuro-ophthalmologic examination, along with a clear understanding of the neuroanatomical pathways, gives clinicians a good diagnostic opportunity to determine the precise location of injuries to the brainstem.
format	article
author	Gonzalez-Arocha Carla Rodriguez-Martinez Ana-Catalina Mohamed-Noriega Jibran
author_facet	Gonzalez-Arocha Carla Rodriguez-Martinez Ana-Catalina Mohamed-Noriega Jibran
author_sort	Gonzalez-Arocha Carla
title	How does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes
title_short	How does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes
title_full	How does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes
title_fullStr	How does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes
title_full_unstemmed	How does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes
title_sort	how does a small area cause big syndromes? a case report of a patient with one-and-a-half syndrome and mri review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8048230fb0b0456f9f5241e105db966e
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How does a small area cause big syndromes? A case report of a patient with one-and-a-half syndrome and MRI review of the anatomical pathways involved in causing different pontine neuro-ophthalmological syndromes

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