Unraveling the mechanisms involved in human norovirus pathogenesis: An update in norovirus pathogenesis

RNA viruses causing human diseases impinge public health and the worldwide economy, as are the case of the current SARS-CoV-2 pandemic. These infectious pathogens are well known to control cellular machinery to complete their replication cycle, specifically taking advantage of the endoplasmic reticu...

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Autores principales:	Magda E. Vera-Garcia, Natalia Martinez-Acuña, Sonia A. Lozano-Sepulveda, Daniel Arellanos-Soto, Kame A. Galan-Huerta, José A. Merino-Mascorro, Javier Ramos-Jiménez, Norma Heredia, Ana Mª Rivas-Estilla
Formato:	article
Lenguaje:	EN ES
Publicado:	Permanyer 2021
Materias:	Norovirus. Endoplasmic reticulum. Unfolded protein response. Proteasome. RNA virus. Acute gastroenteritis. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/804c568a03764591a978cde506af1b0e
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spelling	oai:doaj.org-article:804c568a03764591a978cde506af1b0e2021-12-03T21:50:11ZUnraveling the mechanisms involved in human norovirus pathogenesis: An update in norovirus pathogenesis10.24875/RMU.210000321665-57962530-0709https://doaj.org/article/804c568a03764591a978cde506af1b0e2021-10-01T00:00:00Zhttps://www.medicinauniversitaria.org/frame_esp.php?id=150https://doaj.org/toc/1665-5796https://doaj.org/toc/2530-0709RNA viruses causing human diseases impinge public health and the worldwide economy, as are the case of the current SARS-CoV-2 pandemic. These infectious pathogens are well known to control cellular machinery to complete their replication cycle, specifically taking advantage of the endoplasmic reticulum membrane to build replication complexes (RCs). Norovirus (NV) is a major cause of human gastroenteritis worldwide; this emerging RNA virus is a small positive sense non-enveloped virus belonging to the family Caliciviridae. Recent advances in the development of NV study models have led to an increased understanding of NV replication, pathogenesis, cell tropism, and host immunity response; nonetheless, it remains a challenging pathogen to study due to the lack of a robust model for human NV propagation. Therefore, its pathogenesis is still under characterization. Here, we present an approach to the molecular mechanisms disturbing cellular homeostasis induced by viral protein interactions to specific usage of unfolded protein response and proteasome, cellular processes induced by endoplasmic reticulum stress. Magda E. Vera-GarciaNatalia Martinez-AcuñaSonia A. Lozano-SepulvedaDaniel Arellanos-SotoKame A. Galan-HuertaJosé A. Merino-MascorroJavier Ramos-JiménezNorma HerediaAna Mª Rivas-EstillaPermanyerarticleNorovirus. Endoplasmic reticulum. Unfolded protein response. Proteasome. RNA virus. Acute gastroenteritis.Medicine (General)R5-920ENESMedicina Universitaria, Vol 23, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN ES
topic	Norovirus. Endoplasmic reticulum. Unfolded protein response. Proteasome. RNA virus. Acute gastroenteritis. Medicine (General) R5-920
spellingShingle	Norovirus. Endoplasmic reticulum. Unfolded protein response. Proteasome. RNA virus. Acute gastroenteritis. Medicine (General) R5-920 Magda E. Vera-Garcia Natalia Martinez-Acuña Sonia A. Lozano-Sepulveda Daniel Arellanos-Soto Kame A. Galan-Huerta José A. Merino-Mascorro Javier Ramos-Jiménez Norma Heredia Ana Mª Rivas-Estilla Unraveling the mechanisms involved in human norovirus pathogenesis: An update in norovirus pathogenesis
description	RNA viruses causing human diseases impinge public health and the worldwide economy, as are the case of the current SARS-CoV-2 pandemic. These infectious pathogens are well known to control cellular machinery to complete their replication cycle, specifically taking advantage of the endoplasmic reticulum membrane to build replication complexes (RCs). Norovirus (NV) is a major cause of human gastroenteritis worldwide; this emerging RNA virus is a small positive sense non-enveloped virus belonging to the family Caliciviridae. Recent advances in the development of NV study models have led to an increased understanding of NV replication, pathogenesis, cell tropism, and host immunity response; nonetheless, it remains a challenging pathogen to study due to the lack of a robust model for human NV propagation. Therefore, its pathogenesis is still under characterization. Here, we present an approach to the molecular mechanisms disturbing cellular homeostasis induced by viral protein interactions to specific usage of unfolded protein response and proteasome, cellular processes induced by endoplasmic reticulum stress.
format	article
author	Magda E. Vera-Garcia Natalia Martinez-Acuña Sonia A. Lozano-Sepulveda Daniel Arellanos-Soto Kame A. Galan-Huerta José A. Merino-Mascorro Javier Ramos-Jiménez Norma Heredia Ana Mª Rivas-Estilla
author_facet	Magda E. Vera-Garcia Natalia Martinez-Acuña Sonia A. Lozano-Sepulveda Daniel Arellanos-Soto Kame A. Galan-Huerta José A. Merino-Mascorro Javier Ramos-Jiménez Norma Heredia Ana Mª Rivas-Estilla
author_sort	Magda E. Vera-Garcia
title	Unraveling the mechanisms involved in human norovirus pathogenesis: An update in norovirus pathogenesis
title_short	Unraveling the mechanisms involved in human norovirus pathogenesis: An update in norovirus pathogenesis
title_full	Unraveling the mechanisms involved in human norovirus pathogenesis: An update in norovirus pathogenesis
title_fullStr	Unraveling the mechanisms involved in human norovirus pathogenesis: An update in norovirus pathogenesis
title_full_unstemmed	Unraveling the mechanisms involved in human norovirus pathogenesis: An update in norovirus pathogenesis
title_sort	unraveling the mechanisms involved in human norovirus pathogenesis: an update in norovirus pathogenesis
publisher	Permanyer
publishDate	2021
url	https://doaj.org/article/804c568a03764591a978cde506af1b0e
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Unraveling the mechanisms involved in human norovirus pathogenesis: An update in norovirus pathogenesis

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