Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.

<h4>Objective</h4>Aldehyde dehydrogenase (ALDH) has recently been reported as a marker of cancer stem-like cells in ovarian cancer. However, the prognostic role of ALDH in ovarian cancer still remains controversial. In this study, we aimed to evaluate the association between the expressi...

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Autores principales:	Shuyan Liu, Chengfei Liu, Xiaoyun Min, Yuanyuan Ji, Na Wang, Dan Liu, Jiangyi Cai, Ke Li
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/804c74d02fd54756ace6444a75003bc9
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spelling	oai:doaj.org-article:804c74d02fd54756ace6444a75003bc92021-11-18T08:44:51ZPrognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.1932-620310.1371/journal.pone.0081050https://doaj.org/article/804c74d02fd54756ace6444a75003bc92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24282568/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Aldehyde dehydrogenase (ALDH) has recently been reported as a marker of cancer stem-like cells in ovarian cancer. However, the prognostic role of ALDH in ovarian cancer still remains controversial. In this study, we aimed to evaluate the association between the expression of ALDH and the outcome of ovarian cancer patients by performing a meta-analysis.<h4>Methods</h4>We systematically searched for studies investigating the relationships between ALDH expression and outcome of ovarian cancer patients. Only articles in which ALDH expression was detected by immunohistochemical staining were included. A meta-analysis was performed to generate combined hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) and disease-free survival (DFS).<h4>Results</h4>A total of 1,258 patients from 7 studies (6 articles) were included in the analysis. Our results showed that high ALDH expression in patients with ovarian cancer was associated with poor prognosis in terms of Os (HR, 1.25; 95% CI, 1.07-1.47; P = 0.005) and DFS (HR, 1.58; 95% CI, 1.00-2.49; P = 0.052), though the difference for DFS was not statistically significant. In addition, there was no evidence of publication bias as suggested by Begg's and Egger's tests (Begg's test, P = 0.707; Egger's test, P = 0.355).<h4>Conclusion</h4>The present meta-analysis indicated that elevated ALDH expression was associated with poor prognosis in patients with ovarian cancer.Shuyan LiuChengfei LiuXiaoyun MinYuanyuan JiNa WangDan LiuJiangyi CaiKe LiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81050 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shuyan Liu Chengfei Liu Xiaoyun Min Yuanyuan Ji Na Wang Dan Liu Jiangyi Cai Ke Li Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.
description	<h4>Objective</h4>Aldehyde dehydrogenase (ALDH) has recently been reported as a marker of cancer stem-like cells in ovarian cancer. However, the prognostic role of ALDH in ovarian cancer still remains controversial. In this study, we aimed to evaluate the association between the expression of ALDH and the outcome of ovarian cancer patients by performing a meta-analysis.<h4>Methods</h4>We systematically searched for studies investigating the relationships between ALDH expression and outcome of ovarian cancer patients. Only articles in which ALDH expression was detected by immunohistochemical staining were included. A meta-analysis was performed to generate combined hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) and disease-free survival (DFS).<h4>Results</h4>A total of 1,258 patients from 7 studies (6 articles) were included in the analysis. Our results showed that high ALDH expression in patients with ovarian cancer was associated with poor prognosis in terms of Os (HR, 1.25; 95% CI, 1.07-1.47; P = 0.005) and DFS (HR, 1.58; 95% CI, 1.00-2.49; P = 0.052), though the difference for DFS was not statistically significant. In addition, there was no evidence of publication bias as suggested by Begg's and Egger's tests (Begg's test, P = 0.707; Egger's test, P = 0.355).<h4>Conclusion</h4>The present meta-analysis indicated that elevated ALDH expression was associated with poor prognosis in patients with ovarian cancer.
format	article
author	Shuyan Liu Chengfei Liu Xiaoyun Min Yuanyuan Ji Na Wang Dan Liu Jiangyi Cai Ke Li
author_facet	Shuyan Liu Chengfei Liu Xiaoyun Min Yuanyuan Ji Na Wang Dan Liu Jiangyi Cai Ke Li
author_sort	Shuyan Liu
title	Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.
title_short	Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.
title_full	Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.
title_fullStr	Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.
title_full_unstemmed	Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.
title_sort	prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/804c74d02fd54756ace6444a75003bc9
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_version_	1718421391117647872

Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.

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