Melatonin distribution reveals clues to its biological significance in basal metazoans.

Although nearly ubiquitous in nature, the precise biological significance of endogenous melatonin is poorly understood in phylogenetically basal taxa. In the present work, we describe insights into the functional role of melatonin at the most "basal" level of metazoan evolution. Hitherto u...

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Autores principales:	Modi Roopin, Oren Levy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/804d34f1444f49aea8a653f6c880e729
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spelling	oai:doaj.org-article:804d34f1444f49aea8a653f6c880e7292021-11-18T08:03:44ZMelatonin distribution reveals clues to its biological significance in basal metazoans.1932-620310.1371/journal.pone.0052266https://doaj.org/article/804d34f1444f49aea8a653f6c880e7292012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23300630/?tool=EBIhttps://doaj.org/toc/1932-6203Although nearly ubiquitous in nature, the precise biological significance of endogenous melatonin is poorly understood in phylogenetically basal taxa. In the present work, we describe insights into the functional role of melatonin at the most "basal" level of metazoan evolution. Hitherto unknown morphological determinants of melatonin distribution were evaluated in Nematostella vectensis by detecting melatonin immunoreactivity and examining the spatial gene expression patterns of putative melatonin biosynthetic and receptor elements that are located at opposing ends of the melatonin signaling pathway. Immuno-melatonin profiling indicated an elaborate interaction with reproductive tissues, reinforcing previous conjectures of a melatonin-responsive component in anthozoan reproduction. In situ hybridization (ISH) to putative melatonin receptor elements highlighted the possibility that the bioregulatory effects of melatonin in anthozoan reproduction may be mediated by interactions with membrane receptors, as in higher vertebrates. Another intriguing finding of the present study pertains to the prevalence of melatonin in centralized nervous structures. This pattern may be of great significance given that it 1) identifies an ancestral association between melatonin and key neuronal components and 2) potentially implies that certain effects of melatonin in basal species may be spread widely by regionalized nerve centers.Modi RoopinOren LevyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52266 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Modi Roopin Oren Levy Melatonin distribution reveals clues to its biological significance in basal metazoans.
description	Although nearly ubiquitous in nature, the precise biological significance of endogenous melatonin is poorly understood in phylogenetically basal taxa. In the present work, we describe insights into the functional role of melatonin at the most "basal" level of metazoan evolution. Hitherto unknown morphological determinants of melatonin distribution were evaluated in Nematostella vectensis by detecting melatonin immunoreactivity and examining the spatial gene expression patterns of putative melatonin biosynthetic and receptor elements that are located at opposing ends of the melatonin signaling pathway. Immuno-melatonin profiling indicated an elaborate interaction with reproductive tissues, reinforcing previous conjectures of a melatonin-responsive component in anthozoan reproduction. In situ hybridization (ISH) to putative melatonin receptor elements highlighted the possibility that the bioregulatory effects of melatonin in anthozoan reproduction may be mediated by interactions with membrane receptors, as in higher vertebrates. Another intriguing finding of the present study pertains to the prevalence of melatonin in centralized nervous structures. This pattern may be of great significance given that it 1) identifies an ancestral association between melatonin and key neuronal components and 2) potentially implies that certain effects of melatonin in basal species may be spread widely by regionalized nerve centers.
format	article
author	Modi Roopin Oren Levy
author_facet	Modi Roopin Oren Levy
author_sort	Modi Roopin
title	Melatonin distribution reveals clues to its biological significance in basal metazoans.
title_short	Melatonin distribution reveals clues to its biological significance in basal metazoans.
title_full	Melatonin distribution reveals clues to its biological significance in basal metazoans.
title_fullStr	Melatonin distribution reveals clues to its biological significance in basal metazoans.
title_full_unstemmed	Melatonin distribution reveals clues to its biological significance in basal metazoans.
title_sort	melatonin distribution reveals clues to its biological significance in basal metazoans.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/804d34f1444f49aea8a653f6c880e729
work_keys_str_mv	AT modiroopin melatonindistributionrevealscluestoitsbiologicalsignificanceinbasalmetazoans AT orenlevy melatonindistributionrevealscluestoitsbiologicalsignificanceinbasalmetazoans
_version_	1718422430967398400

Melatonin distribution reveals clues to its biological significance in basal metazoans.

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