Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration. Herein, a pure silk fibroin (SF) hydrogel with a combination of high-strength and aligned microgrooved topographic structure is reported. The h...

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Autores principales:	Gu Xinyi, Chen Xiaoli, Tang Xiaoxuan, Zhou Zhihao, Huang Tingting, Yang Yumin, Ling Jue
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	silk fibroin hydrogel micropattern peripheral nerve regeneration Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
Acceso en línea:	https://doaj.org/article/804da949a55044eea6350e42ca0c7660
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spelling	oai:doaj.org-article:804da949a55044eea6350e42ca0c76602021-12-05T14:10:57ZPure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration2191-909710.1515/ntrev-2021-0002https://doaj.org/article/804da949a55044eea6350e42ca0c76602021-02-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0002https://doaj.org/toc/2191-9097Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration. Herein, a pure silk fibroin (SF) hydrogel with a combination of high-strength and aligned microgrooved topographic structure is reported. The hydrogels exhibit excellent mechanical properties with high strength. Good biocompatibility also allows the hydrogels to support cell survival. Significantly, the hydrogel with aligned microgrooved structures enables the aligned growth of Schwann cells. Moreover, the hydrogel holds a strong capacity for promoting axon growth and guiding neurite sprouting. Thus, this micropatterned SF hydrogel would have great potential for peripheral nerve regeneration.Gu XinyiChen XiaoliTang XiaoxuanZhou ZhihaoHuang TingtingYang YuminLing JueDe Gruyterarticlesilk fibroinhydrogelmicropatternperipheral nerve regenerationTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 10-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	silk fibroin hydrogel micropattern peripheral nerve regeneration Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
spellingShingle	silk fibroin hydrogel micropattern peripheral nerve regeneration Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Gu Xinyi Chen Xiaoli Tang Xiaoxuan Zhou Zhihao Huang Tingting Yang Yumin Ling Jue Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
description	Successful repair of long-distance peripheral nerve injuries remains a challenge in the clinic. Rapid axon growth is a key to accelerate nerve regeneration. Herein, a pure silk fibroin (SF) hydrogel with a combination of high-strength and aligned microgrooved topographic structure is reported. The hydrogels exhibit excellent mechanical properties with high strength. Good biocompatibility also allows the hydrogels to support cell survival. Significantly, the hydrogel with aligned microgrooved structures enables the aligned growth of Schwann cells. Moreover, the hydrogel holds a strong capacity for promoting axon growth and guiding neurite sprouting. Thus, this micropatterned SF hydrogel would have great potential for peripheral nerve regeneration.
format	article
author	Gu Xinyi Chen Xiaoli Tang Xiaoxuan Zhou Zhihao Huang Tingting Yang Yumin Ling Jue
author_facet	Gu Xinyi Chen Xiaoli Tang Xiaoxuan Zhou Zhihao Huang Tingting Yang Yumin Ling Jue
author_sort	Gu Xinyi
title	Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
title_short	Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
title_full	Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
title_fullStr	Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
title_full_unstemmed	Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
title_sort	pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/804da949a55044eea6350e42ca0c7660
work_keys_str_mv	AT guxinyi puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT chenxiaoli puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT tangxiaoxuan puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT zhouzhihao puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT huangtingting puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT yangyumin puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration AT lingjue puresilkfibroinhydrogelwithstablealignedmicropatterntowardperipheralnerveregeneration
_version_	1718371550633132032

Pure-silk fibroin hydrogel with stable aligned micropattern toward peripheral nerve regeneration

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