Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models

Abstract A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-bas...

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Autores principales:	Youngmi Koo, Tarannum Tiasha, Vesselin N. Shanov, Yeoheung Yun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/805003679f8c405e8705e7060380d120
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spelling	oai:doaj.org-article:805003679f8c405e8705e7060380d1202021-12-02T11:40:51ZExpandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models10.1038/s41598-017-01214-42045-2322https://doaj.org/article/805003679f8c405e8705e7060380d1202017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01214-4https://doaj.org/toc/2045-2322Abstract A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-based helical stent was inserted and expanded in vessels with subsequent degradation in various environments including static, dynamic, and porcine ex vivo models. By assessing stent degradation in three different environments, we observed: (1) stress- and flow-induced degradation; (2) a high degradation rate in the dynamic reactor; (3) production of intermediate products (MgO/Mg(OH)2 and Ca/P) during degradation; and (4) intermediate micro-gas pocket formation in the neighboring tissue ex vivo model. Overall, the expandable Mg-based helical stent employed as a scaffold performed well, with expansion rate (>100%) in porcine ex vivo model.Youngmi KooTarannum TiashaVesselin N. ShanovYeoheung YunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Youngmi Koo Tarannum Tiasha Vesselin N. Shanov Yeoheung Yun Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models
description	Abstract A bioresorbable metallic helical stent was explored as a new device opportunity (magnesium scaffold), which can be absorbed by the body without leaving a trace and simultaneously allowing restoration of vasoreactivity with the potential for vessel remodeling. In this study, developed Mg-based helical stent was inserted and expanded in vessels with subsequent degradation in various environments including static, dynamic, and porcine ex vivo models. By assessing stent degradation in three different environments, we observed: (1) stress- and flow-induced degradation; (2) a high degradation rate in the dynamic reactor; (3) production of intermediate products (MgO/Mg(OH)2 and Ca/P) during degradation; and (4) intermediate micro-gas pocket formation in the neighboring tissue ex vivo model. Overall, the expandable Mg-based helical stent employed as a scaffold performed well, with expansion rate (>100%) in porcine ex vivo model.
format	article
author	Youngmi Koo Tarannum Tiasha Vesselin N. Shanov Yeoheung Yun
author_facet	Youngmi Koo Tarannum Tiasha Vesselin N. Shanov Yeoheung Yun
author_sort	Youngmi Koo
title	Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models
title_short	Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models
title_full	Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models
title_fullStr	Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models
title_full_unstemmed	Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models
title_sort	expandable mg-based helical stent assessment using static, dynamic, and porcine ex vivo models
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/805003679f8c405e8705e7060380d120
work_keys_str_mv	AT youngmikoo expandablemgbasedhelicalstentassessmentusingstaticdynamicandporcineexvivomodels AT tarannumtiasha expandablemgbasedhelicalstentassessmentusingstaticdynamicandporcineexvivomodels AT vesselinnshanov expandablemgbasedhelicalstentassessmentusingstaticdynamicandporcineexvivomodels AT yeoheungyun expandablemgbasedhelicalstentassessmentusingstaticdynamicandporcineexvivomodels
_version_	1718395526451298304

Expandable Mg-based Helical Stent Assessment using Static, Dynamic, and Porcine Ex Vivo Models

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