Accessibility of the histone H3 tail in the nucleosome for binding of paired readers

The chromatin remodeller CHD4 contains two PHD finger reader domains that have been shown to bivalently recognize H3 histone tails. Here, the authors describe a mechanism by which the PHD fingers bind to the intact nucleosome core particle, revealing both cooperative and individual interactions.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jovylyn Gatchalian, Xiaodong Wang, Jinzen Ikebe, Khan L. Cox, Adam H. Tencer, Yi Zhang, Nathaniel L. Burge, Luo Di, Matthew D. Gibson, Catherine A. Musselman, Michael G. Poirier, Hidetoshi Kono, Jeffrey J. Hayes, Tatiana G. Kutateladze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80503b36d74a4bc3b72aa20bc28f7b84
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:80503b36d74a4bc3b72aa20bc28f7b84
record_format	dspace
spelling	oai:doaj.org-article:80503b36d74a4bc3b72aa20bc28f7b842021-12-02T15:39:03ZAccessibility of the histone H3 tail in the nucleosome for binding of paired readers10.1038/s41467-017-01598-x2041-1723https://doaj.org/article/80503b36d74a4bc3b72aa20bc28f7b842017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01598-xhttps://doaj.org/toc/2041-1723The chromatin remodeller CHD4 contains two PHD finger reader domains that have been shown to bivalently recognize H3 histone tails. Here, the authors describe a mechanism by which the PHD fingers bind to the intact nucleosome core particle, revealing both cooperative and individual interactions.Jovylyn GatchalianXiaodong WangJinzen IkebeKhan L. CoxAdam H. TencerYi ZhangNathaniel L. BurgeLuo DiMatthew D. GibsonCatherine A. MusselmanMichael G. PoirierHidetoshi KonoJeffrey J. HayesTatiana G. KutateladzeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jovylyn Gatchalian Xiaodong Wang Jinzen Ikebe Khan L. Cox Adam H. Tencer Yi Zhang Nathaniel L. Burge Luo Di Matthew D. Gibson Catherine A. Musselman Michael G. Poirier Hidetoshi Kono Jeffrey J. Hayes Tatiana G. Kutateladze Accessibility of the histone H3 tail in the nucleosome for binding of paired readers
description	The chromatin remodeller CHD4 contains two PHD finger reader domains that have been shown to bivalently recognize H3 histone tails. Here, the authors describe a mechanism by which the PHD fingers bind to the intact nucleosome core particle, revealing both cooperative and individual interactions.
format	article
author	Jovylyn Gatchalian Xiaodong Wang Jinzen Ikebe Khan L. Cox Adam H. Tencer Yi Zhang Nathaniel L. Burge Luo Di Matthew D. Gibson Catherine A. Musselman Michael G. Poirier Hidetoshi Kono Jeffrey J. Hayes Tatiana G. Kutateladze
author_facet	Jovylyn Gatchalian Xiaodong Wang Jinzen Ikebe Khan L. Cox Adam H. Tencer Yi Zhang Nathaniel L. Burge Luo Di Matthew D. Gibson Catherine A. Musselman Michael G. Poirier Hidetoshi Kono Jeffrey J. Hayes Tatiana G. Kutateladze
author_sort	Jovylyn Gatchalian
title	Accessibility of the histone H3 tail in the nucleosome for binding of paired readers
title_short	Accessibility of the histone H3 tail in the nucleosome for binding of paired readers
title_full	Accessibility of the histone H3 tail in the nucleosome for binding of paired readers
title_fullStr	Accessibility of the histone H3 tail in the nucleosome for binding of paired readers
title_full_unstemmed	Accessibility of the histone H3 tail in the nucleosome for binding of paired readers
title_sort	accessibility of the histone h3 tail in the nucleosome for binding of paired readers
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/80503b36d74a4bc3b72aa20bc28f7b84
work_keys_str_mv	AT jovylyngatchalian accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT xiaodongwang accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT jinzenikebe accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT khanlcox accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT adamhtencer accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT yizhang accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT nathaniellburge accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT luodi accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT matthewdgibson accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT catherineamusselman accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT michaelgpoirier accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT hidetoshikono accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT jeffreyjhayes accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders AT tatianagkutateladze accessibilityofthehistoneh3tailinthenucleosomeforbindingofpairedreaders
_version_	1718385997909065728

Accessibility of the histone H3 tail in the nucleosome for binding of paired readers

Ejemplares similares