JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells

Neurogenesis is an ordered transition from pluriptotent cells to neural precursor cells (NPCs) to neurons. Here the authors show that loss of the lysine demethylases JMJD3 and UTX leads reduced DNA accessibility at neurogenesis loci in human NPCs, and that the chromatin remodeller BAF can rescue dif...

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Autores principales:	Yongli Shan, Yanqi Zhang, Yuan Zhao, Tianyu Wang, Jingyuan Zhang, Jiao Yao, Ning Ma, Zechuan Liang, Wenhao Huang, Ke Huang, Tian Zhang, Zhenghui Su, Qianyu Chen, Yanling Zhu, Chuman Wu, Tiancheng Zhou, Wei Sun, Yanxing Wei, Cong Zhang, Chenxu Li, Shuquan Su, Baojian Liao, Mei Zhong, Xiaofen Zhong, Jinfu Nie, Duanqing Pei, Guangjin Pan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/80505987d5cf4b679818c2110e0c8333
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:80505987d5cf4b679818c2110e0c83332021-12-02T14:40:39ZJMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells10.1038/s41467-019-14028-x2041-1723https://doaj.org/article/80505987d5cf4b679818c2110e0c83332020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14028-xhttps://doaj.org/toc/2041-1723Neurogenesis is an ordered transition from pluriptotent cells to neural precursor cells (NPCs) to neurons. Here the authors show that loss of the lysine demethylases JMJD3 and UTX leads reduced DNA accessibility at neurogenesis loci in human NPCs, and that the chromatin remodeller BAF can rescue differentiation defects.Yongli ShanYanqi ZhangYuan ZhaoTianyu WangJingyuan ZhangJiao YaoNing MaZechuan LiangWenhao HuangKe HuangTian ZhangZhenghui SuQianyu ChenYanling ZhuChuman WuTiancheng ZhouWei SunYanxing WeiCong ZhangChenxu LiShuquan SuBaojian LiaoMei ZhongXiaofen ZhongJinfu NieDuanqing PeiGuangjin PanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yongli Shan Yanqi Zhang Yuan Zhao Tianyu Wang Jingyuan Zhang Jiao Yao Ning Ma Zechuan Liang Wenhao Huang Ke Huang Tian Zhang Zhenghui Su Qianyu Chen Yanling Zhu Chuman Wu Tiancheng Zhou Wei Sun Yanxing Wei Cong Zhang Chenxu Li Shuquan Su Baojian Liao Mei Zhong Xiaofen Zhong Jinfu Nie Duanqing Pei Guangjin Pan JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells
description	Neurogenesis is an ordered transition from pluriptotent cells to neural precursor cells (NPCs) to neurons. Here the authors show that loss of the lysine demethylases JMJD3 and UTX leads reduced DNA accessibility at neurogenesis loci in human NPCs, and that the chromatin remodeller BAF can rescue differentiation defects.
format	article
author	Yongli Shan Yanqi Zhang Yuan Zhao Tianyu Wang Jingyuan Zhang Jiao Yao Ning Ma Zechuan Liang Wenhao Huang Ke Huang Tian Zhang Zhenghui Su Qianyu Chen Yanling Zhu Chuman Wu Tiancheng Zhou Wei Sun Yanxing Wei Cong Zhang Chenxu Li Shuquan Su Baojian Liao Mei Zhong Xiaofen Zhong Jinfu Nie Duanqing Pei Guangjin Pan
author_facet	Yongli Shan Yanqi Zhang Yuan Zhao Tianyu Wang Jingyuan Zhang Jiao Yao Ning Ma Zechuan Liang Wenhao Huang Ke Huang Tian Zhang Zhenghui Su Qianyu Chen Yanling Zhu Chuman Wu Tiancheng Zhou Wei Sun Yanxing Wei Cong Zhang Chenxu Li Shuquan Su Baojian Liao Mei Zhong Xiaofen Zhong Jinfu Nie Duanqing Pei Guangjin Pan
author_sort	Yongli Shan
title	JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells
title_short	JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells
title_full	JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells
title_fullStr	JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells
title_full_unstemmed	JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells
title_sort	jmjd3 and utx determine fidelity and lineage specification of human neural progenitor cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/80505987d5cf4b679818c2110e0c8333
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JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells

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