Early sorafenib-induced toxicity is associated with drug exposure and UGTIA9 genetic polymorphism in patients with solid tumors: a preliminary study.

Early sorafenib-induced toxicity is associated with drug exposure and UGTIA9 genetic polymorphism in patients with solid tumors: a preliminary study.

<h4>Background</h4>Identifying predictive biomarkers of drug response is of key importance to improve therapy management and drug selection in cancer therapy. To date, the influence of drug exposure and pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The...

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Autores principales: Pascaline Boudou-Rouquette, Céline Narjoz, Jean Louis Golmard, Audrey Thomas-Schoemann, Olivier Mir, Fabrice Taieb, Jean-Philippe Durand, Romain Coriat, Alain Dauphin, Michel Vidal, Michel Tod, Marie-Anne Loriot, François Goldwasser, Benoit Blanchet
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/80507bd316a74a50b6e32edbe689dc73
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