Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX

2,5-Dihydroxypyridine dioxygenase NicX uses a mononuclear non-heme Fe(II) to catalyze the oxidative pyridine ring cleavage of the pollutant 2,5-hydroxypyridine. Here, the authors report crystal structures of NicX, identify residues involved in substrate stabilization and Fe(II) coordination, and pro...

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Autores principales:	Gongquan Liu, Yi-Lei Zhao, Fangyuan He, Peng Zhang, Xingyu Ouyang, Hongzhi Tang, Ping Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8056cf6f1a90486493e8ec3a75248635
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spelling	oai:doaj.org-article:8056cf6f1a90486493e8ec3a752486352021-12-02T13:33:01ZStructure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX10.1038/s41467-021-21567-92041-1723https://doaj.org/article/8056cf6f1a90486493e8ec3a752486352021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21567-9https://doaj.org/toc/2041-17232,5-Dihydroxypyridine dioxygenase NicX uses a mononuclear non-heme Fe(II) to catalyze the oxidative pyridine ring cleavage of the pollutant 2,5-hydroxypyridine. Here, the authors report crystal structures of NicX, identify residues involved in substrate stabilization and Fe(II) coordination, and propose the catalytic mechanism of NicX.Gongquan LiuYi-Lei ZhaoFangyuan HePeng ZhangXingyu OuyangHongzhi TangPing XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gongquan Liu Yi-Lei Zhao Fangyuan He Peng Zhang Xingyu Ouyang Hongzhi Tang Ping Xu Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX
description	2,5-Dihydroxypyridine dioxygenase NicX uses a mononuclear non-heme Fe(II) to catalyze the oxidative pyridine ring cleavage of the pollutant 2,5-hydroxypyridine. Here, the authors report crystal structures of NicX, identify residues involved in substrate stabilization and Fe(II) coordination, and propose the catalytic mechanism of NicX.
format	article
author	Gongquan Liu Yi-Lei Zhao Fangyuan He Peng Zhang Xingyu Ouyang Hongzhi Tang Ping Xu
author_facet	Gongquan Liu Yi-Lei Zhao Fangyuan He Peng Zhang Xingyu Ouyang Hongzhi Tang Ping Xu
author_sort	Gongquan Liu
title	Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX
title_short	Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX
title_full	Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX
title_fullStr	Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX
title_full_unstemmed	Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX
title_sort	structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme fe (ii) dioxygenase nicx
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8056cf6f1a90486493e8ec3a75248635
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_version_	1718392864322355200

Structure-guided insights into heterocyclic ring-cleavage catalysis of the non-heme Fe (II) dioxygenase NicX

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