Outcomes of Alvimopan Use in Laparoscopic Intra-abdominal Surgery: A Retrospective Review

Background: Postoperative ileus is a transient cessation of bowel motility, occurring after bowel resection, characterized by abdominal distension and pain, nausea, vomiting, and an accumulation of gas/fluids in the bowel. It is associated with a greater incidence of postoperative morbidity and inc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aamir A. Kokan, Sahil Sheth, Katherine Rogers
Formato:	article
Lenguaje:	EN
Publicado:	University of Minnesota Libraries Publishing 2021
Materias:	alvimopan, postoperative ileus, laparoscopic, intra-abdominal surgery Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/8059c993548b4d6ebcbb72b6f7370bdd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8059c993548b4d6ebcbb72b6f7370bdd
record_format	dspace
spelling	oai:doaj.org-article:8059c993548b4d6ebcbb72b6f7370bdd2021-12-05T18:44:04ZOutcomes of Alvimopan Use in Laparoscopic Intra-abdominal Surgery: A Retrospective Review10.24926/iip.v12i4.39692155-0417https://doaj.org/article/8059c993548b4d6ebcbb72b6f7370bdd2021-11-01T00:00:00Zhttps://pubs.lib.umn.edu/index.php/innovations/article/view/3969https://doaj.org/toc/2155-0417 Background: Postoperative ileus is a transient cessation of bowel motility, occurring after bowel resection, characterized by abdominal distension and pain, nausea, vomiting, and an accumulation of gas/fluids in the bowel. It is associated with a greater incidence of postoperative morbidity and increased length of stay or readmission. Alvimopan, a novel peripheral mu receptor antagonist, is indicated for preventing postoperative ileus in patients undergoing intra-abdominal surgery or bowel resection. The objective of this study was to assess the impact of alvimopan use in laparoscopic abdominal surgeries. Objective: To assess alvimopan use’s impact in laparoscopic abdominal surgeries. Methods: A retrospective chart review was conducted of 84 patients who underwent laparoscopic procedures that received alvimopan (September 1, 2018 to October 31, 2018) and compared to patients that did not receive alvimopan (May 1, 2018 to June 30, 2018, due to a national shortage of the medication). The primary outcome was the rate of postoperative ileus. Secondary outcomes included rate of 30-day readmission, length of stay (LOS), postoperative opioid and laxative use, time to initiation of oral diet, and return of bowel function (ROBF) as demonstrated by recorded bowel movement. Results: There was no statistical difference observed in primary outcome of postoperative ileus between alvimopan and no alvimopan groups (2.7% vs 4.3%, p=1). Secondary outcomes such as length of stay (5.4 days vs 5.4 days, p=0.49), length of postoperative stay (5 vs 4.9, p=0.44), days to oral diet (0.9 vs 0.4, p=0.16), time to BM (1.8 vs 2.2, p=0.32), and 30-day readmission were also similar between the two groups. Conclusion: The similar outcome profiles in all primary and secondary outcomes do not support the use of alvimopan in the setting of laparoscopic intra-abdominal surgery. Aamir A. KokanSahil ShethKatherine RogersUniversity of Minnesota Libraries Publishingarticlealvimopan, postoperative ileus, laparoscopic, intra-abdominal surgeryPharmacy and materia medicaRS1-441ENINNOVATIONS in Pharmacy, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alvimopan, postoperative ileus, laparoscopic, intra-abdominal surgery Pharmacy and materia medica RS1-441
spellingShingle	alvimopan, postoperative ileus, laparoscopic, intra-abdominal surgery Pharmacy and materia medica RS1-441 Aamir A. Kokan Sahil Sheth Katherine Rogers Outcomes of Alvimopan Use in Laparoscopic Intra-abdominal Surgery: A Retrospective Review
description	Background: Postoperative ileus is a transient cessation of bowel motility, occurring after bowel resection, characterized by abdominal distension and pain, nausea, vomiting, and an accumulation of gas/fluids in the bowel. It is associated with a greater incidence of postoperative morbidity and increased length of stay or readmission. Alvimopan, a novel peripheral mu receptor antagonist, is indicated for preventing postoperative ileus in patients undergoing intra-abdominal surgery or bowel resection. The objective of this study was to assess the impact of alvimopan use in laparoscopic abdominal surgeries. Objective: To assess alvimopan use’s impact in laparoscopic abdominal surgeries. Methods: A retrospective chart review was conducted of 84 patients who underwent laparoscopic procedures that received alvimopan (September 1, 2018 to October 31, 2018) and compared to patients that did not receive alvimopan (May 1, 2018 to June 30, 2018, due to a national shortage of the medication). The primary outcome was the rate of postoperative ileus. Secondary outcomes included rate of 30-day readmission, length of stay (LOS), postoperative opioid and laxative use, time to initiation of oral diet, and return of bowel function (ROBF) as demonstrated by recorded bowel movement. Results: There was no statistical difference observed in primary outcome of postoperative ileus between alvimopan and no alvimopan groups (2.7% vs 4.3%, p=1). Secondary outcomes such as length of stay (5.4 days vs 5.4 days, p=0.49), length of postoperative stay (5 vs 4.9, p=0.44), days to oral diet (0.9 vs 0.4, p=0.16), time to BM (1.8 vs 2.2, p=0.32), and 30-day readmission were also similar between the two groups. Conclusion: The similar outcome profiles in all primary and secondary outcomes do not support the use of alvimopan in the setting of laparoscopic intra-abdominal surgery.
format	article
author	Aamir A. Kokan Sahil Sheth Katherine Rogers
author_facet	Aamir A. Kokan Sahil Sheth Katherine Rogers
author_sort	Aamir A. Kokan
title	Outcomes of Alvimopan Use in Laparoscopic Intra-abdominal Surgery: A Retrospective Review
title_short	Outcomes of Alvimopan Use in Laparoscopic Intra-abdominal Surgery: A Retrospective Review
title_full	Outcomes of Alvimopan Use in Laparoscopic Intra-abdominal Surgery: A Retrospective Review
title_fullStr	Outcomes of Alvimopan Use in Laparoscopic Intra-abdominal Surgery: A Retrospective Review
title_full_unstemmed	Outcomes of Alvimopan Use in Laparoscopic Intra-abdominal Surgery: A Retrospective Review
title_sort	outcomes of alvimopan use in laparoscopic intra-abdominal surgery: a retrospective review
publisher	University of Minnesota Libraries Publishing
publishDate	2021
url	https://doaj.org/article/8059c993548b4d6ebcbb72b6f7370bdd
work_keys_str_mv	AT aamirakokan outcomesofalvimopanuseinlaparoscopicintraabdominalsurgeryaretrospectivereview AT sahilsheth outcomesofalvimopanuseinlaparoscopicintraabdominalsurgeryaretrospectivereview AT katherinerogers outcomesofalvimopanuseinlaparoscopicintraabdominalsurgeryaretrospectivereview
_version_	1718371076134666240

Outcomes of Alvimopan Use in Laparoscopic Intra-abdominal Surgery: A Retrospective Review

Ejemplares similares