Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children

Background: The link between parasitic infestation and allergic diseases or unexplained neurologic manifestations was hypothesized, especially in children. However, the debate continues regarding this link. Aim of the work: To determine the seroprevalence of toxocariasis in children with different a...

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Autores principales:	Khaled Aly Temsah, Mostafa Elshahat Mostafa, Hany Abdul Hady El-Khaleegy, Atef Wahdan El Rifai, Mona Abd Raboo, Sherief M. Al shazly
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	bronchial asthma children toxocariasis epilepsy chronic urticaria Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/805c9f31874445589239688b0da7028f
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spelling	oai:doaj.org-article:805c9f31874445589239688b0da7028f2021-12-02T14:33:23ZToxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children2636-41742682-378010.21608/ijma.2020.46359.1192https://doaj.org/article/805c9f31874445589239688b0da7028f2021-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_124697_358715ec66e08ffd5e459117e63835a6.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: The link between parasitic infestation and allergic diseases or unexplained neurologic manifestations was hypothesized, especially in children. However, the debate continues regarding this link. Aim of the work: To determine the seroprevalence of toxocariasis in children with different allergic diseases [bronchial asthma and skin allergy], besides the unexplained neurological manifestations [epilepsy and focal neurologic deficits] in children. Patients and methods: Children with bronchial asthma [40 children], skin allergy [40 children], and unexplained neurological manifestations [epilepsy and focal neurologic deficits], [40 children] were included. All underwent a full history taking, clinical examination, lab investigations, and seropositivity determination for Toxocara canis. Results:Eosinophilia was reported in 22.5%, 30.0%, and 17.5% of asthma, skin, and unexplained neurological manifestations groups, respectively. In patients with asthma, the prevalence of toxocariasis was 15.0%; in skin disease, it was 7.5%, and in unexplained neurological manifestations, it was 12.5%. There was no significant difference between positive and negative toxocariasis regarding patient demographics. But there was a significant increase in contact with pets, chronic urticaria, lymph nodes involvement, and eosinophilia in positive when compared to negative groups. Conclusion: The association between Toxocara canis infection and allergic diseases such as bronchial asthma, chronic urticaria, and unexplained neurological manifestations [epilepsy and focal neurologic deficits] was confirmed in the present work. The contact with dogs and cats [pets] was the major determinant risk factor explaining such association. Prospective cohort studies were warranted to examine the cause-effect relationship.Khaled Aly TemsahMostafa Elshahat MostafaHany Abdul Hady El-KhaleegyAtef Wahdan El RifaiMona Abd RabooSherief M. Al shazlyAl-Azhar University, Faculty of Medicine (Damietta)articlebronchial asthmachildrentoxocariasisepilepsychronic urticariaMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 1, Pp 922-929 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bronchial asthma children toxocariasis epilepsy chronic urticaria Medicine (General) R5-920
spellingShingle	bronchial asthma children toxocariasis epilepsy chronic urticaria Medicine (General) R5-920 Khaled Aly Temsah Mostafa Elshahat Mostafa Hany Abdul Hady El-Khaleegy Atef Wahdan El Rifai Mona Abd Raboo Sherief M. Al shazly Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children
description	Background: The link between parasitic infestation and allergic diseases or unexplained neurologic manifestations was hypothesized, especially in children. However, the debate continues regarding this link. Aim of the work: To determine the seroprevalence of toxocariasis in children with different allergic diseases [bronchial asthma and skin allergy], besides the unexplained neurological manifestations [epilepsy and focal neurologic deficits] in children. Patients and methods: Children with bronchial asthma [40 children], skin allergy [40 children], and unexplained neurological manifestations [epilepsy and focal neurologic deficits], [40 children] were included. All underwent a full history taking, clinical examination, lab investigations, and seropositivity determination for Toxocara canis. Results:Eosinophilia was reported in 22.5%, 30.0%, and 17.5% of asthma, skin, and unexplained neurological manifestations groups, respectively. In patients with asthma, the prevalence of toxocariasis was 15.0%; in skin disease, it was 7.5%, and in unexplained neurological manifestations, it was 12.5%. There was no significant difference between positive and negative toxocariasis regarding patient demographics. But there was a significant increase in contact with pets, chronic urticaria, lymph nodes involvement, and eosinophilia in positive when compared to negative groups. Conclusion: The association between Toxocara canis infection and allergic diseases such as bronchial asthma, chronic urticaria, and unexplained neurological manifestations [epilepsy and focal neurologic deficits] was confirmed in the present work. The contact with dogs and cats [pets] was the major determinant risk factor explaining such association. Prospective cohort studies were warranted to examine the cause-effect relationship.
format	article
author	Khaled Aly Temsah Mostafa Elshahat Mostafa Hany Abdul Hady El-Khaleegy Atef Wahdan El Rifai Mona Abd Raboo Sherief M. Al shazly
author_facet	Khaled Aly Temsah Mostafa Elshahat Mostafa Hany Abdul Hady El-Khaleegy Atef Wahdan El Rifai Mona Abd Raboo Sherief M. Al shazly
author_sort	Khaled Aly Temsah
title	Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children
title_short	Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children
title_full	Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children
title_fullStr	Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children
title_full_unstemmed	Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children
title_sort	toxocariasis; a neglected tropical disease, association with asthma, chronic urticaria and unexplained neurologic manifestations among children
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/805c9f31874445589239688b0da7028f
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Toxocariasis; A Neglected Tropical Disease, Association With Asthma, Chronic Urticaria and Unexplained Neurologic Manifestations Among Children

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