Neurobehavioral burden of multiple sclerosis with nanotheranostics

Bhasker Sriramoju, Rupinder K Kanwar, Jagat R Kanwar Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine, Molecular and Medical Research, Faculty of Health, Deakin University, VIC, Australia Abstract: Multiple sclerosis (MS) is a chronic demyelinati...

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Autores principales:	Sriramoju B, Kanwar RK, Kanwar JR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8061bea6a1dd4d9f9fd5bc99ab872cf6
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spelling	oai:doaj.org-article:8061bea6a1dd4d9f9fd5bc99ab872cf62021-12-02T07:43:10ZNeurobehavioral burden of multiple sclerosis with nanotheranostics1178-2021https://doaj.org/article/8061bea6a1dd4d9f9fd5bc99ab872cf62015-10-01T00:00:00Zhttps://www.dovepress.com/neurobehavioral-burden-of-multiple-sclerosis-withnbspnanotheranostics-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Bhasker Sriramoju, Rupinder K Kanwar, Jagat R Kanwar Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine, Molecular and Medical Research, Faculty of Health, Deakin University, VIC, Australia Abstract: Multiple sclerosis (MS) is a chronic demyelinating neurological disorder affecting people worldwide; women are affected more than men. MS results in serious neurological deficits along with behavioral compromise, the mechanisms of which still remain unclear. Behavioral disturbances such as depression, anxiety, cognitive impairment, psychosis, euphoria, sleep disturbances, and fatigue affect the quality of life in MS patients. Among these, depression and psychosis are more common than any other neurological disorders. In addition, depression is associated with other comorbidities. Although anxiety is often misdiagnosed in MS patients, it can induce suicidal ideation if it coexists with depression. An interrelation between sleep abnormalities and fatigue is also reported among MS patients. In addition, therapeutics for MS is always a challenge because of the presence of the blood–brain barrier, adding to the lack of detailed understanding of the disease pathology. In this review, we tried to summarize various behavioral pathologies and their association with MS, followed by its conventional treatment and nanotheranostics. Keywords: demyelination, behavioral disorders, behavioral testsSriramoju BKanwar RKKanwar JRDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2675-2689 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Sriramoju B Kanwar RK Kanwar JR Neurobehavioral burden of multiple sclerosis with nanotheranostics
description	Bhasker Sriramoju, Rupinder K Kanwar, Jagat R Kanwar Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine, Molecular and Medical Research, Faculty of Health, Deakin University, VIC, Australia Abstract: Multiple sclerosis (MS) is a chronic demyelinating neurological disorder affecting people worldwide; women are affected more than men. MS results in serious neurological deficits along with behavioral compromise, the mechanisms of which still remain unclear. Behavioral disturbances such as depression, anxiety, cognitive impairment, psychosis, euphoria, sleep disturbances, and fatigue affect the quality of life in MS patients. Among these, depression and psychosis are more common than any other neurological disorders. In addition, depression is associated with other comorbidities. Although anxiety is often misdiagnosed in MS patients, it can induce suicidal ideation if it coexists with depression. An interrelation between sleep abnormalities and fatigue is also reported among MS patients. In addition, therapeutics for MS is always a challenge because of the presence of the blood–brain barrier, adding to the lack of detailed understanding of the disease pathology. In this review, we tried to summarize various behavioral pathologies and their association with MS, followed by its conventional treatment and nanotheranostics. Keywords: demyelination, behavioral disorders, behavioral tests
format	article
author	Sriramoju B Kanwar RK Kanwar JR
author_facet	Sriramoju B Kanwar RK Kanwar JR
author_sort	Sriramoju B
title	Neurobehavioral burden of multiple sclerosis with nanotheranostics
title_short	Neurobehavioral burden of multiple sclerosis with nanotheranostics
title_full	Neurobehavioral burden of multiple sclerosis with nanotheranostics
title_fullStr	Neurobehavioral burden of multiple sclerosis with nanotheranostics
title_full_unstemmed	Neurobehavioral burden of multiple sclerosis with nanotheranostics
title_sort	neurobehavioral burden of multiple sclerosis with nanotheranostics
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/8061bea6a1dd4d9f9fd5bc99ab872cf6
work_keys_str_mv	AT sriramojub neurobehavioralburdenofmultiplesclerosiswithnbspnanotheranostics AT kanwarrk neurobehavioralburdenofmultiplesclerosiswithnbspnanotheranostics AT kanwarjr neurobehavioralburdenofmultiplesclerosiswithnbspnanotheranostics
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Neurobehavioral burden of multiple sclerosis with&nbsp;nanotheranostics

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Neurobehavioral burden of multiple sclerosis with nanotheranostics