Serum neurotrophin profile in systemic sclerosis.

<h4>Background</h4>Neurotrophins (NTs) are able to activate lymphocytes and fibroblasts; they can modulate angiogenesis and sympathic vascular function. Thus, they can be implicated in the three pathogenic processes of systemic sclerosis (SSc). The aims of this study are to determine blo...

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Autores principales:	Marie-Claude Lise, Agnès Sparsa, Isabelle Marie, Fabrice Lalloué, Kim Ly, Clothilde Martel, Holy Bezanahary, Guillaume Gondran, Véronique Loustaud-Ratti, Jean-Marie Bonnetblanc, Elisabeth Vidal, Marie-Odile Jauberteau, Anne-Laure Fauchais
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/80668d91a0ea48c39b5c14c0ac22a42e
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spelling	oai:doaj.org-article:80668d91a0ea48c39b5c14c0ac22a42e2021-11-18T07:37:02ZSerum neurotrophin profile in systemic sclerosis.1932-620310.1371/journal.pone.0013918https://doaj.org/article/80668d91a0ea48c39b5c14c0ac22a42e2010-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21085492/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Neurotrophins (NTs) are able to activate lymphocytes and fibroblasts; they can modulate angiogenesis and sympathic vascular function. Thus, they can be implicated in the three pathogenic processes of systemic sclerosis (SSc). The aims of this study are to determine blood levels of Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) in SSc and to correlate them with clinical and biological data.<h4>Methods</h4>Serum samples were obtained from 55 SSc patients and 32 control subjects to measure NTs levels by ELISA and to determine their relationships with SSc profiles.<h4>Findings</h4>Serum NGF levels were higher in SSc patients (288.26 ± 170.34 pg/mL) than in control subjects (170.34 ± 50.8 pg/mL, p<0.001) and correlated with gammaglobulins levels and the presence of both anti-cardiolipin and anti-Scl-70 antibodies (p<0.05). In contrast, BDNF levels were lower in SSc patients than in controls (1121.9 ± 158.1 vs 1372.9 ± 190.9 pg/mL, p<0.0001), especially in pulmonary arterial hypertension and diffuse SSc as compared to limited forms (all p<0.05). NT-3 levels were similar in SSc and in the control group (2657.2 ± 2296 vs 2959.3 ± 2555 pg/mL, NS). BDNF levels correlated negatively with increased NGF levels in the SSc group (and not in controls).<h4>Conclusion</h4>Low BDNF serum levels were not previously documented in SSc, particularly in the diffuse SSc subset and in patients with pulmonary hypertension or anti-Scl-70 antibodies. The negative correlation between NGF and BDNF levels observed in SSc and not in healthy controls could be implicated in sympathic vascular dysfunction in SSc.Marie-Claude LiseAgnès SparsaIsabelle MarieFabrice LallouéKim LyClothilde MartelHoly BezanaharyGuillaume GondranVéronique Loustaud-RattiJean-Marie BonnetblancElisabeth VidalMarie-Odile JauberteauAnne-Laure FauchaisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 11, p e13918 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie-Claude Lise Agnès Sparsa Isabelle Marie Fabrice Lalloué Kim Ly Clothilde Martel Holy Bezanahary Guillaume Gondran Véronique Loustaud-Ratti Jean-Marie Bonnetblanc Elisabeth Vidal Marie-Odile Jauberteau Anne-Laure Fauchais Serum neurotrophin profile in systemic sclerosis.
description	<h4>Background</h4>Neurotrophins (NTs) are able to activate lymphocytes and fibroblasts; they can modulate angiogenesis and sympathic vascular function. Thus, they can be implicated in the three pathogenic processes of systemic sclerosis (SSc). The aims of this study are to determine blood levels of Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) in SSc and to correlate them with clinical and biological data.<h4>Methods</h4>Serum samples were obtained from 55 SSc patients and 32 control subjects to measure NTs levels by ELISA and to determine their relationships with SSc profiles.<h4>Findings</h4>Serum NGF levels were higher in SSc patients (288.26 ± 170.34 pg/mL) than in control subjects (170.34 ± 50.8 pg/mL, p<0.001) and correlated with gammaglobulins levels and the presence of both anti-cardiolipin and anti-Scl-70 antibodies (p<0.05). In contrast, BDNF levels were lower in SSc patients than in controls (1121.9 ± 158.1 vs 1372.9 ± 190.9 pg/mL, p<0.0001), especially in pulmonary arterial hypertension and diffuse SSc as compared to limited forms (all p<0.05). NT-3 levels were similar in SSc and in the control group (2657.2 ± 2296 vs 2959.3 ± 2555 pg/mL, NS). BDNF levels correlated negatively with increased NGF levels in the SSc group (and not in controls).<h4>Conclusion</h4>Low BDNF serum levels were not previously documented in SSc, particularly in the diffuse SSc subset and in patients with pulmonary hypertension or anti-Scl-70 antibodies. The negative correlation between NGF and BDNF levels observed in SSc and not in healthy controls could be implicated in sympathic vascular dysfunction in SSc.
format	article
author	Marie-Claude Lise Agnès Sparsa Isabelle Marie Fabrice Lalloué Kim Ly Clothilde Martel Holy Bezanahary Guillaume Gondran Véronique Loustaud-Ratti Jean-Marie Bonnetblanc Elisabeth Vidal Marie-Odile Jauberteau Anne-Laure Fauchais
author_facet	Marie-Claude Lise Agnès Sparsa Isabelle Marie Fabrice Lalloué Kim Ly Clothilde Martel Holy Bezanahary Guillaume Gondran Véronique Loustaud-Ratti Jean-Marie Bonnetblanc Elisabeth Vidal Marie-Odile Jauberteau Anne-Laure Fauchais
author_sort	Marie-Claude Lise
title	Serum neurotrophin profile in systemic sclerosis.
title_short	Serum neurotrophin profile in systemic sclerosis.
title_full	Serum neurotrophin profile in systemic sclerosis.
title_fullStr	Serum neurotrophin profile in systemic sclerosis.
title_full_unstemmed	Serum neurotrophin profile in systemic sclerosis.
title_sort	serum neurotrophin profile in systemic sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/80668d91a0ea48c39b5c14c0ac22a42e
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Serum neurotrophin profile in systemic sclerosis.

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