Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.

Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected c...

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Autores principales:	Guangzhi Yang, Boshen Wang, Dawei Sun, Huimin Wang, Mengyao Chen, Hao Chen, Baoli Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/806e04d05e5f4f768b34bf214a290db9
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spelling	oai:doaj.org-article:806e04d05e5f4f768b34bf214a290db92021-12-02T20:11:22ZGenetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.1932-620310.1371/journal.pone.0251090https://doaj.org/article/806e04d05e5f4f768b34bf214a290db92021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251090https://doaj.org/toc/1932-6203Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.Guangzhi YangBoshen WangDawei SunHuimin WangMengyao ChenHao ChenBaoli ZhuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251090 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guangzhi Yang Boshen Wang Dawei Sun Huimin Wang Mengyao Chen Hao Chen Baoli Zhu Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
description	Noise-induced-hearing-loss(NIHL) is a common occupational disease caused by various environmental and biological factors. To investigate the association between TAB2 and the susceptibility of NIHL of people exposed to occupational environments, a genetic association study was performed on selected companies with 588 cases and 537 healthy control subjects. Five selected single nucleotide polymorphisms (SNPs) in TAB2,incoluding rs2744434, rs521845, rs652921, rs7896, rs9485372, were genotyped after a collection of DNA samples. Evident differences in participants between the case group and the control group reveals the result that people with the TAB2 has a high probability of getting NIHL. The results show that rs521845 is deeply associated with the risk of NIHL and is available for the diagnosis in the future.
format	article
author	Guangzhi Yang Boshen Wang Dawei Sun Huimin Wang Mengyao Chen Hao Chen Baoli Zhu
author_facet	Guangzhi Yang Boshen Wang Dawei Sun Huimin Wang Mengyao Chen Hao Chen Baoli Zhu
author_sort	Guangzhi Yang
title	Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
title_short	Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
title_full	Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
title_fullStr	Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
title_full_unstemmed	Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.
title_sort	genetic association study between tab2 polymorphisms and noise-induced-hearing-loss in a han chinese population.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/806e04d05e5f4f768b34bf214a290db9
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Genetic association study between TAB2 polymorphisms and noise-induced-hearing-loss in a Han Chinese population.

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