KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
The molecular details of the RAS-RAF interaction are still not fully understood. Here, the authors present crystal structures of wild-type and mutant KRAS in complex with the RAS-binding and membrane-interacting cysteine-rich domains of RAF1, and propose a model of the membrane-bound RAS-RAF complex...
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Nature Portfolio
2021
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oai:doaj.org-article:8075c5993bfb4f61bc8bb5d4533213372021-12-02T10:52:48ZKRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation10.1038/s41467-021-21422-x2041-1723https://doaj.org/article/8075c5993bfb4f61bc8bb5d4533213372021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21422-xhttps://doaj.org/toc/2041-1723The molecular details of the RAS-RAF interaction are still not fully understood. Here, the authors present crystal structures of wild-type and mutant KRAS in complex with the RAS-binding and membrane-interacting cysteine-rich domains of RAF1, and propose a model of the membrane-bound RAS-RAF complex.Timothy H. TranAlbert H. ChanLucy C. YoungLakshman BinduChris NealeSimon MessingSrisathiyanarayanan DharmaiahTroy TaylorJohn-Paul DensonDominic EspositoDwight V. NissleyAndrew G. StephenFrank McCormickDhirendra K. SimanshuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Timothy H. Tran Albert H. Chan Lucy C. Young Lakshman Bindu Chris Neale Simon Messing Srisathiyanarayanan Dharmaiah Troy Taylor John-Paul Denson Dominic Esposito Dwight V. Nissley Andrew G. Stephen Frank McCormick Dhirendra K. Simanshu KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation |
| description |
The molecular details of the RAS-RAF interaction are still not fully understood. Here, the authors present crystal structures of wild-type and mutant KRAS in complex with the RAS-binding and membrane-interacting cysteine-rich domains of RAF1, and propose a model of the membrane-bound RAS-RAF complex. |
| format |
article |
| author |
Timothy H. Tran Albert H. Chan Lucy C. Young Lakshman Bindu Chris Neale Simon Messing Srisathiyanarayanan Dharmaiah Troy Taylor John-Paul Denson Dominic Esposito Dwight V. Nissley Andrew G. Stephen Frank McCormick Dhirendra K. Simanshu |
| author_facet |
Timothy H. Tran Albert H. Chan Lucy C. Young Lakshman Bindu Chris Neale Simon Messing Srisathiyanarayanan Dharmaiah Troy Taylor John-Paul Denson Dominic Esposito Dwight V. Nissley Andrew G. Stephen Frank McCormick Dhirendra K. Simanshu |
| author_sort |
Timothy H. Tran |
| title |
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation |
| title_short |
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation |
| title_full |
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation |
| title_fullStr |
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation |
| title_full_unstemmed |
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation |
| title_sort |
kras interaction with raf1 ras-binding domain and cysteine-rich domain provides insights into ras-mediated raf activation |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8075c5993bfb4f61bc8bb5d453321337 |
| work_keys_str_mv |
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