Potential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance

Nanotechnology has become an emerging technology in the medical field and is widely applicable for various clinical applications. The potential use of nanoparticles as antimicrobial agents is greatly explored and taken into consideration as alternative methods to overcome the challenges faced by hea...

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Autores principales:	Maheswary Thambirajoo, Manira Maarof, Yogeswaran Lokanathan, Haliza Katas, Nur Fatiha Ghazalli, Yasuhiko Tabata, Mh Busra Fauzi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanoparticles antimicrobial agents pathogenic microorganisms biofilm formations antibiotic resistance clinical settings Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8078328541e648af9edca1a8e29f3e6d
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spelling	oai:doaj.org-article:8078328541e648af9edca1a8e29f3e6d2021-11-25T16:23:06ZPotential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance10.3390/antibiotics101113382079-6382https://doaj.org/article/8078328541e648af9edca1a8e29f3e6d2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1338https://doaj.org/toc/2079-6382Nanotechnology has become an emerging technology in the medical field and is widely applicable for various clinical applications. The potential use of nanoparticles as antimicrobial agents is greatly explored and taken into consideration as alternative methods to overcome the challenges faced by healthcare workers and patients in preventing infections caused by pathogenic microorganisms. Among microorganisms, bacterial infections remain a major hurdle and are responsible for high morbidity and mortality globally, especially involving those with medical conditions and elderly populations. Over time, these groups are more vulnerable to developing resistance to antibiotics, as bacterial biofilms are difficult to destroy or eliminate via antibiotics; thus, treatment becomes unsuccessful or ineffective. Mostly, bacterial biofilms and other microbes can be found on medical devices and wounds where they disperse their contents which cause infections. To inhibit biofilm formations and overcome antibiotic resistance, antimicrobial-loaded nanoparticles alone or combined with other substances could enhance the bactericidal activity of nanomaterials. This includes killing the pathogens effectively without harming other cells or causing any adverse effects to living cells. This review summarises the mechanisms of actions employed by the different types of nanoparticles which counteract infectious agents in reducing biofilm formation and improve antibiotic therapy for clinical usage.Maheswary ThambirajooManira MaarofYogeswaran LokanathanHaliza KatasNur Fatiha GhazalliYasuhiko TabataMh Busra FauziMDPI AGarticlenanoparticlesantimicrobial agentspathogenic microorganismsbiofilm formationsantibiotic resistanceclinical settingsTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1338, p 1338 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles antimicrobial agents pathogenic microorganisms biofilm formations antibiotic resistance clinical settings Therapeutics. Pharmacology RM1-950
spellingShingle	nanoparticles antimicrobial agents pathogenic microorganisms biofilm formations antibiotic resistance clinical settings Therapeutics. Pharmacology RM1-950 Maheswary Thambirajoo Manira Maarof Yogeswaran Lokanathan Haliza Katas Nur Fatiha Ghazalli Yasuhiko Tabata Mh Busra Fauzi Potential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance
description	Nanotechnology has become an emerging technology in the medical field and is widely applicable for various clinical applications. The potential use of nanoparticles as antimicrobial agents is greatly explored and taken into consideration as alternative methods to overcome the challenges faced by healthcare workers and patients in preventing infections caused by pathogenic microorganisms. Among microorganisms, bacterial infections remain a major hurdle and are responsible for high morbidity and mortality globally, especially involving those with medical conditions and elderly populations. Over time, these groups are more vulnerable to developing resistance to antibiotics, as bacterial biofilms are difficult to destroy or eliminate via antibiotics; thus, treatment becomes unsuccessful or ineffective. Mostly, bacterial biofilms and other microbes can be found on medical devices and wounds where they disperse their contents which cause infections. To inhibit biofilm formations and overcome antibiotic resistance, antimicrobial-loaded nanoparticles alone or combined with other substances could enhance the bactericidal activity of nanomaterials. This includes killing the pathogens effectively without harming other cells or causing any adverse effects to living cells. This review summarises the mechanisms of actions employed by the different types of nanoparticles which counteract infectious agents in reducing biofilm formation and improve antibiotic therapy for clinical usage.
format	article
author	Maheswary Thambirajoo Manira Maarof Yogeswaran Lokanathan Haliza Katas Nur Fatiha Ghazalli Yasuhiko Tabata Mh Busra Fauzi
author_facet	Maheswary Thambirajoo Manira Maarof Yogeswaran Lokanathan Haliza Katas Nur Fatiha Ghazalli Yasuhiko Tabata Mh Busra Fauzi
author_sort	Maheswary Thambirajoo
title	Potential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance
title_short	Potential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance
title_full	Potential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance
title_fullStr	Potential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance
title_full_unstemmed	Potential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance
title_sort	potential of nanoparticles integrated with antibacterial properties in preventing biofilm and antibiotic resistance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8078328541e648af9edca1a8e29f3e6d
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Potential of Nanoparticles Integrated with Antibacterial Properties in Preventing Biofilm and Antibiotic Resistance

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