Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation

Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation

Niche crosstalk with Haematopoietic cells underlies normal haematopoiesis and myeloid disorders. Here the authors report a Stabilin2-Cre driver mouse with Cre-activity restricted to bone marrow sinusoidal endothelial cells, and that Stabilin2-Cre driven overactivation of b-catenin leads to erythroid...

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Auteurs principaux: Joschka Heil, Victor Olsavszky, Katrin Busch, Kay Klapproth, Carolina de la Torre, Carsten Sticht, Kajetan Sandorski, Johannes Hoffmann, Hiltrud Schönhaber, Johanna Zierow, Manuel Winkler, Christian David Schmid, Theresa Staniczek, Deborah E. Daniels, Jan Frayne, Georgia Metzgeroth, Daniel Nowak, Sven Schneider, Michael Neumaier, Vanessa Weyer, Christoph Groden, Hermann-Josef Gröne, Karsten Richter, Carolin Mogler, Makoto Mark Taketo, Kai Schledzewski, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Koch
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/807900d34c274dcfa83939c240d17adf
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Résumé:Niche crosstalk with Haematopoietic cells underlies normal haematopoiesis and myeloid disorders. Here the authors report a Stabilin2-Cre driver mouse with Cre-activity restricted to bone marrow sinusoidal endothelial cells, and that Stabilin2-Cre driven overactivation of b-catenin leads to erythroid differentiation defects and anaemia.

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