Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation

Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation

Niche crosstalk with Haematopoietic cells underlies normal haematopoiesis and myeloid disorders. Here the authors report a Stabilin2-Cre driver mouse with Cre-activity restricted to bone marrow sinusoidal endothelial cells, and that Stabilin2-Cre driven overactivation of b-catenin leads to erythroid...

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Autores principales: Joschka Heil, Victor Olsavszky, Katrin Busch, Kay Klapproth, Carolina de la Torre, Carsten Sticht, Kajetan Sandorski, Johannes Hoffmann, Hiltrud Schönhaber, Johanna Zierow, Manuel Winkler, Christian David Schmid, Theresa Staniczek, Deborah E. Daniels, Jan Frayne, Georgia Metzgeroth, Daniel Nowak, Sven Schneider, Michael Neumaier, Vanessa Weyer, Christoph Groden, Hermann-Josef Gröne, Karsten Richter, Carolin Mogler, Makoto Mark Taketo, Kai Schledzewski, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Koch
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/807900d34c274dcfa83939c240d17adf
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spelling oai:doaj.org-article:807900d34c274dcfa83939c240d17adf2021-12-05T12:22:16ZBone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation10.1038/s41467-021-27161-32041-1723https://doaj.org/article/807900d34c274dcfa83939c240d17adf2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27161-3https://doaj.org/toc/2041-1723Niche crosstalk with Haematopoietic cells underlies normal haematopoiesis and myeloid disorders. Here the authors report a Stabilin2-Cre driver mouse with Cre-activity restricted to bone marrow sinusoidal endothelial cells, and that Stabilin2-Cre driven overactivation of b-catenin leads to erythroid differentiation defects and anaemia.Joschka HeilVictor OlsavszkyKatrin BuschKay KlapprothCarolina de la TorreCarsten StichtKajetan SandorskiJohannes HoffmannHiltrud SchönhaberJohanna ZierowManuel WinklerChristian David SchmidTheresa StaniczekDeborah E. DanielsJan FrayneGeorgia MetzgerothDaniel NowakSven SchneiderMichael NeumaierVanessa WeyerChristoph GrodenHermann-Josef GröneKarsten RichterCarolin MoglerMakoto Mark TaketoKai SchledzewskiCyrill GéraudSergij GoerdtPhilipp-Sebastian KochNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Joschka Heil
Victor Olsavszky
Katrin Busch
Kay Klapproth
Carolina de la Torre
Carsten Sticht
Kajetan Sandorski
Johannes Hoffmann
Hiltrud Schönhaber
Johanna Zierow
Manuel Winkler
Christian David Schmid
Theresa Staniczek
Deborah E. Daniels
Jan Frayne
Georgia Metzgeroth
Daniel Nowak
Sven Schneider
Michael Neumaier
Vanessa Weyer
Christoph Groden
Hermann-Josef Gröne
Karsten Richter
Carolin Mogler
Makoto Mark Taketo
Kai Schledzewski
Cyrill Géraud
Sergij Goerdt
Philipp-Sebastian Koch
Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
description Niche crosstalk with Haematopoietic cells underlies normal haematopoiesis and myeloid disorders. Here the authors report a Stabilin2-Cre driver mouse with Cre-activity restricted to bone marrow sinusoidal endothelial cells, and that Stabilin2-Cre driven overactivation of b-catenin leads to erythroid differentiation defects and anaemia.
format article
author Joschka Heil
Victor Olsavszky
Katrin Busch
Kay Klapproth
Carolina de la Torre
Carsten Sticht
Kajetan Sandorski
Johannes Hoffmann
Hiltrud Schönhaber
Johanna Zierow
Manuel Winkler
Christian David Schmid
Theresa Staniczek
Deborah E. Daniels
Jan Frayne
Georgia Metzgeroth
Daniel Nowak
Sven Schneider
Michael Neumaier
Vanessa Weyer
Christoph Groden
Hermann-Josef Gröne
Karsten Richter
Carolin Mogler
Makoto Mark Taketo
Kai Schledzewski
Cyrill Géraud
Sergij Goerdt
Philipp-Sebastian Koch
author_facet Joschka Heil
Victor Olsavszky
Katrin Busch
Kay Klapproth
Carolina de la Torre
Carsten Sticht
Kajetan Sandorski
Johannes Hoffmann
Hiltrud Schönhaber
Johanna Zierow
Manuel Winkler
Christian David Schmid
Theresa Staniczek
Deborah E. Daniels
Jan Frayne
Georgia Metzgeroth
Daniel Nowak
Sven Schneider
Michael Neumaier
Vanessa Weyer
Christoph Groden
Hermann-Josef Gröne
Karsten Richter
Carolin Mogler
Makoto Mark Taketo
Kai Schledzewski
Cyrill Géraud
Sergij Goerdt
Philipp-Sebastian Koch
author_sort Joschka Heil
title Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
title_short Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
title_full Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
title_fullStr Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
title_full_unstemmed Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
title_sort bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/807900d34c274dcfa83939c240d17adf
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