Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases

PDZ (postsynaptic density (PSD95), discs large (Dlg), and zonula occludens (ZO-1)-dependent interactions are widely distributed within different cell types and regulate a variety of cellular processes. To date, some of these interactions have been identified as targets of small molecules or peptides...

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Autores principales:	Luis H. Gutiérrez-González, Selma Rivas-Fuentes, Silvia Guzmán-Beltrán, Angélica Flores-Flores, Jorge Rosas-García, Teresa Santos-Mendoza
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	PDZ domains PDZ-dependent interactions peptide inhibitors immune-related disorders Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/80792aa8f59444318df3a4b1f8dd9c2c
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spelling	oai:doaj.org-article:80792aa8f59444318df3a4b1f8dd9c2c2021-11-11T18:23:47ZPeptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases10.3390/molecules262163671420-3049https://doaj.org/article/80792aa8f59444318df3a4b1f8dd9c2c2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6367https://doaj.org/toc/1420-3049PDZ (postsynaptic density (PSD95), discs large (Dlg), and zonula occludens (ZO-1)-dependent interactions are widely distributed within different cell types and regulate a variety of cellular processes. To date, some of these interactions have been identified as targets of small molecules or peptides, mainly related to central nervous system disorders and cancer. Recently, the knowledge of PDZ proteins and their interactions has been extended to various cell types of the immune system, suggesting that their targeting by viral pathogens may constitute an immune evasion mechanism that favors viral replication and dissemination. Thus, the pharmacological modulation of these interactions, either with small molecules or peptides, could help in the control of some immune-related diseases. Deeper structural and functional knowledge of this kind of protein–protein interactions, especially in immune cells, will uncover novel pharmacological targets for a diversity of clinical conditions.Luis H. Gutiérrez-GonzálezSelma Rivas-FuentesSilvia Guzmán-BeltránAngélica Flores-FloresJorge Rosas-GarcíaTeresa Santos-MendozaMDPI AGarticlePDZ domainsPDZ-dependent interactionspeptide inhibitorsimmune-related disordersOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6367, p 6367 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PDZ domains PDZ-dependent interactions peptide inhibitors immune-related disorders Organic chemistry QD241-441
spellingShingle	PDZ domains PDZ-dependent interactions peptide inhibitors immune-related disorders Organic chemistry QD241-441 Luis H. Gutiérrez-González Selma Rivas-Fuentes Silvia Guzmán-Beltrán Angélica Flores-Flores Jorge Rosas-García Teresa Santos-Mendoza Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases
description	PDZ (postsynaptic density (PSD95), discs large (Dlg), and zonula occludens (ZO-1)-dependent interactions are widely distributed within different cell types and regulate a variety of cellular processes. To date, some of these interactions have been identified as targets of small molecules or peptides, mainly related to central nervous system disorders and cancer. Recently, the knowledge of PDZ proteins and their interactions has been extended to various cell types of the immune system, suggesting that their targeting by viral pathogens may constitute an immune evasion mechanism that favors viral replication and dissemination. Thus, the pharmacological modulation of these interactions, either with small molecules or peptides, could help in the control of some immune-related diseases. Deeper structural and functional knowledge of this kind of protein–protein interactions, especially in immune cells, will uncover novel pharmacological targets for a diversity of clinical conditions.
format	article
author	Luis H. Gutiérrez-González Selma Rivas-Fuentes Silvia Guzmán-Beltrán Angélica Flores-Flores Jorge Rosas-García Teresa Santos-Mendoza
author_facet	Luis H. Gutiérrez-González Selma Rivas-Fuentes Silvia Guzmán-Beltrán Angélica Flores-Flores Jorge Rosas-García Teresa Santos-Mendoza
author_sort	Luis H. Gutiérrez-González
title	Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases
title_short	Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases
title_full	Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases
title_fullStr	Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases
title_full_unstemmed	Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases
title_sort	peptide targeting of pdz-dependent interactions as pharmacological intervention in immune-related diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/80792aa8f59444318df3a4b1f8dd9c2c
work_keys_str_mv	AT luishgutierrezgonzalez peptidetargetingofpdzdependentinteractionsaspharmacologicalinterventioninimmunerelateddiseases AT selmarivasfuentes peptidetargetingofpdzdependentinteractionsaspharmacologicalinterventioninimmunerelateddiseases AT silviaguzmanbeltran peptidetargetingofpdzdependentinteractionsaspharmacologicalinterventioninimmunerelateddiseases AT angelicafloresflores peptidetargetingofpdzdependentinteractionsaspharmacologicalinterventioninimmunerelateddiseases AT jorgerosasgarcia peptidetargetingofpdzdependentinteractionsaspharmacologicalinterventioninimmunerelateddiseases AT teresasantosmendoza peptidetargetingofpdzdependentinteractionsaspharmacologicalinterventioninimmunerelateddiseases
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Peptide Targeting of PDZ-Dependent Interactions as Pharmacological Intervention in Immune-Related Diseases

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