IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice

Carolin Koss et al. show that IL-36 produced from neutrophils is a key amplifier of lung inflammation in mice by activating neutrophils, macrophages and fibroblasts in cooperation with GM-CSF and the viral mimic poly(I:C). This study suggests that targeting IL-36 may improve the treatment of neutrop...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carolin K. Koss, Christian T. Wohnhaas, Jonathan R. Baker, Cornelia Tilp, Michèl Przibilla, Carmen Lerner, Silvia Frey, Martina Keck, Cara M. M. Williams, Daniel Peter, Meera Ramanujam, Jay Fine, Florian Gantner, Matthew Thomas, Peter J. Barnes, Louise E. Donnelly, Karim C. El Kasmi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/807afab62a534fbbbb0ab4d532e4b447
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:807afab62a534fbbbb0ab4d532e4b447
record_format	dspace
spelling	oai:doaj.org-article:807afab62a534fbbbb0ab4d532e4b4472021-12-02T14:26:53ZIL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice10.1038/s42003-021-01703-32399-3642https://doaj.org/article/807afab62a534fbbbb0ab4d532e4b4472021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01703-3https://doaj.org/toc/2399-3642Carolin Koss et al. show that IL-36 produced from neutrophils is a key amplifier of lung inflammation in mice by activating neutrophils, macrophages and fibroblasts in cooperation with GM-CSF and the viral mimic poly(I:C). This study suggests that targeting IL-36 may improve the treatment of neutrophilic lung diseases.Carolin K. KossChristian T. WohnhaasJonathan R. BakerCornelia TilpMichèl PrzibillaCarmen LernerSilvia FreyMartina KeckCara M. M. WilliamsDaniel PeterMeera RamanujamJay FineFlorian GantnerMatthew ThomasPeter J. BarnesLouise E. DonnellyKarim C. El KasmiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Carolin K. Koss Christian T. Wohnhaas Jonathan R. Baker Cornelia Tilp Michèl Przibilla Carmen Lerner Silvia Frey Martina Keck Cara M. M. Williams Daniel Peter Meera Ramanujam Jay Fine Florian Gantner Matthew Thomas Peter J. Barnes Louise E. Donnelly Karim C. El Kasmi IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
description	Carolin Koss et al. show that IL-36 produced from neutrophils is a key amplifier of lung inflammation in mice by activating neutrophils, macrophages and fibroblasts in cooperation with GM-CSF and the viral mimic poly(I:C). This study suggests that targeting IL-36 may improve the treatment of neutrophilic lung diseases.
format	article
author	Carolin K. Koss Christian T. Wohnhaas Jonathan R. Baker Cornelia Tilp Michèl Przibilla Carmen Lerner Silvia Frey Martina Keck Cara M. M. Williams Daniel Peter Meera Ramanujam Jay Fine Florian Gantner Matthew Thomas Peter J. Barnes Louise E. Donnelly Karim C. El Kasmi
author_facet	Carolin K. Koss Christian T. Wohnhaas Jonathan R. Baker Cornelia Tilp Michèl Przibilla Carmen Lerner Silvia Frey Martina Keck Cara M. M. Williams Daniel Peter Meera Ramanujam Jay Fine Florian Gantner Matthew Thomas Peter J. Barnes Louise E. Donnelly Karim C. El Kasmi
author_sort	Carolin K. Koss
title	IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
title_short	IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
title_full	IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
title_fullStr	IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
title_full_unstemmed	IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
title_sort	il36 is a critical upstream amplifier of neutrophilic lung inflammation in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/807afab62a534fbbbb0ab4d532e4b447
work_keys_str_mv	AT carolinkkoss il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT christiantwohnhaas il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT jonathanrbaker il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT corneliatilp il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT michelprzibilla il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT carmenlerner il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT silviafrey il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT martinakeck il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT carammwilliams il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT danielpeter il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT meeraramanujam il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT jayfine il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT floriangantner il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT matthewthomas il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT peterjbarnes il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT louiseedonnelly il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice AT karimcelkasmi il36isacriticalupstreamamplifierofneutrophiliclunginflammationinmice
_version_	1718391320958992384

IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice

Ejemplares similares