Eradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility

Antibiotics: Enhanced effect with an electrical scaffold Using an electrically conductive fabric to generate hydrogen peroxide could eradicate persistent biofilms in chronically infected wounds. Electrochemical scaffolds (e-scaffolds) are thin networks of conductive material such as carbon fiber use...

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Autores principales:	Sujala T Sultana, Douglas R Call, Haluk Beyenal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/807b2c34c163427baf35515801830df2
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spelling	oai:doaj.org-article:807b2c34c163427baf35515801830df22021-12-02T15:10:26ZEradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility10.1038/s41522-016-0003-02055-5008https://doaj.org/article/807b2c34c163427baf35515801830df22016-11-01T00:00:00Zhttps://doi.org/10.1038/s41522-016-0003-0https://doaj.org/toc/2055-5008Antibiotics: Enhanced effect with an electrical scaffold Using an electrically conductive fabric to generate hydrogen peroxide could eradicate persistent biofilms in chronically infected wounds. Electrochemical scaffolds (e-scaffolds) are thin networks of conductive material such as carbon fiber used to generate chemical responses in media they are in contact with. Haluk Beyenal and colleagues at Washington State University, USA, investigated the effect of a carbon fabric e-scaffold on cultured biofilms of the bacterium Pseudomonas aeruginosa. The procedure enhanced the susceptibility of this troublesome multidrug-resistant bacterium to the antibiotic tobramycin. Crucially, it eradicated so-called persister cells that can evade antibiotic treatment to reform biofilms in chronic wounds. The research suggests that the effect involves the production of hydroxyl free radicals from hydrogen peroxide and increased permeability of the bacterial cell membranes. The potential of e-scaffolds for treating infected wounds warrants further exploration.Sujala T SultanaDouglas R CallHaluk BeyenalNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 2, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Sujala T Sultana Douglas R Call Haluk Beyenal Eradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility
description	Antibiotics: Enhanced effect with an electrical scaffold Using an electrically conductive fabric to generate hydrogen peroxide could eradicate persistent biofilms in chronically infected wounds. Electrochemical scaffolds (e-scaffolds) are thin networks of conductive material such as carbon fiber used to generate chemical responses in media they are in contact with. Haluk Beyenal and colleagues at Washington State University, USA, investigated the effect of a carbon fabric e-scaffold on cultured biofilms of the bacterium Pseudomonas aeruginosa. The procedure enhanced the susceptibility of this troublesome multidrug-resistant bacterium to the antibiotic tobramycin. Crucially, it eradicated so-called persister cells that can evade antibiotic treatment to reform biofilms in chronic wounds. The research suggests that the effect involves the production of hydroxyl free radicals from hydrogen peroxide and increased permeability of the bacterial cell membranes. The potential of e-scaffolds for treating infected wounds warrants further exploration.
format	article
author	Sujala T Sultana Douglas R Call Haluk Beyenal
author_facet	Sujala T Sultana Douglas R Call Haluk Beyenal
author_sort	Sujala T Sultana
title	Eradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility
title_short	Eradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility
title_full	Eradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility
title_fullStr	Eradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility
title_full_unstemmed	Eradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility
title_sort	eradication of pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/807b2c34c163427baf35515801830df2
work_keys_str_mv	AT sujalatsultana eradicationofpseudomonasaeruginosabiofilmsandpersistercellsusinganelectrochemicalscaffoldandenhancedantibioticsusceptibility AT douglasrcall eradicationofpseudomonasaeruginosabiofilmsandpersistercellsusinganelectrochemicalscaffoldandenhancedantibioticsusceptibility AT halukbeyenal eradicationofpseudomonasaeruginosabiofilmsandpersistercellsusinganelectrochemicalscaffoldandenhancedantibioticsusceptibility
_version_	1718387700616134656

Eradication of Pseudomonas aeruginosa biofilms and persister cells using an electrochemical scaffold and enhanced antibiotic susceptibility

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