Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Abstract Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to ind...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/807b6c00d37f4d82bde110d6936e5ef0 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:807b6c00d37f4d82bde110d6936e5ef0 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:807b6c00d37f4d82bde110d6936e5ef02021-12-02T12:31:50ZRor2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness10.1038/s41598-016-0028-x2045-2322https://doaj.org/article/807b6c00d37f4d82bde110d6936e5ef02017-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-016-0028-xhttps://doaj.org/toc/2045-2322Abstract Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the invasiveness of these tumors. We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion. Furthermore, IFT20 promotes the efficiency of transport through the Golgi complex. These findings shed new insights into how Ror2 signaling promotes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can be regulated.Michiru NishitaSeung-Yeol ParkTadashi NishioKoki KamizakiZhiChao WangKota TamadaToru TakumiRyuju HashimotoHiroki OtaniGregory J. PazourVictor W. HsuYasuhiro MinamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Michiru Nishita Seung-Yeol Park Tadashi Nishio Koki Kamizaki ZhiChao Wang Kota Tamada Toru Takumi Ryuju Hashimoto Hiroki Otani Gregory J. Pazour Victor W. Hsu Yasuhiro Minami Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness |
| description |
Abstract Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability of Ror2 signaling to induce the invasiveness of these tumors. We also find that IFT20 regulates the nucleation of Golgi-derived microtubules by affecting the GM130-AKAP450 complex, which promotes Golgi ribbon formation in achieving polarized secretion for cell migration and invasion. Furthermore, IFT20 promotes the efficiency of transport through the Golgi complex. These findings shed new insights into how Ror2 signaling promotes tumor invasiveness, and also advance the understanding of how Golgi structure and transport can be regulated. |
| format |
article |
| author |
Michiru Nishita Seung-Yeol Park Tadashi Nishio Koki Kamizaki ZhiChao Wang Kota Tamada Toru Takumi Ryuju Hashimoto Hiroki Otani Gregory J. Pazour Victor W. Hsu Yasuhiro Minami |
| author_facet |
Michiru Nishita Seung-Yeol Park Tadashi Nishio Koki Kamizaki ZhiChao Wang Kota Tamada Toru Takumi Ryuju Hashimoto Hiroki Otani Gregory J. Pazour Victor W. Hsu Yasuhiro Minami |
| author_sort |
Michiru Nishita |
| title |
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness |
| title_short |
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness |
| title_full |
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness |
| title_fullStr |
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness |
| title_full_unstemmed |
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness |
| title_sort |
ror2 signaling regulates golgi structure and transport through ift20 for tumor invasiveness |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/807b6c00d37f4d82bde110d6936e5ef0 |
| work_keys_str_mv |
AT michirunishita ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT seungyeolpark ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT tadashinishio ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT kokikamizaki ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT zhichaowang ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT kotatamada ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT torutakumi ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT ryujuhashimoto ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT hirokiotani ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT gregoryjpazour ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT victorwhsu ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness AT yasuhirominami ror2signalingregulatesgolgistructureandtransportthroughift20fortumorinvasiveness |
| _version_ |
1718394287771615232 |