SERUM SECRETORY IMMUNOGLOBULIN A AND Gln223Arg POLYMORPHISM OF THE LEPR GENE IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES

Level of serum secretory immunoglobulin A was investigated in alcoholic liver disease (ALD, 59 men and 23 women) and non-alcoholic fatty liver disease (NAFLD, 17 men and 93 women).The data were compared with those of persons without liver pathology (control group, 43 men and 73 women). Moreover, we...

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Autores principales:	N. V. Mal’tseva, O. F. Lykova, A. V. Morozova, S. V. Arkhipova, Ya. A. Gorbatovskii
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	serum secretory iga lepr gene polymorphism hepatic disorders Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/807c19d7a2564b1ea63ead4e4244c3b0
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spelling	oai:doaj.org-article:807c19d7a2564b1ea63ead4e4244c3b02021-11-18T08:03:44ZSERUM SECRETORY IMMUNOGLOBULIN A AND Gln223Arg POLYMORPHISM OF THE LEPR GENE IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES1563-06252313-741X10.15789/1563-0625-2014-5-465-472https://doaj.org/article/807c19d7a2564b1ea63ead4e4244c3b02014-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/734https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XLevel of serum secretory immunoglobulin A was investigated in alcoholic liver disease (ALD, 59 men and 23 women) and non-alcoholic fatty liver disease (NAFLD, 17 men and 93 women).The data were compared with those of persons without liver pathology (control group, 43 men and 73 women). Moreover, we studied possible associations between ssIgA level and Gln223Arg polymorphism of the LEPR gene. Immunological and DNA diagnostics was performed by means of, respectively, ELISA and allele-specific polymerase chain reaction. We have found that the average level of ssIgA was three times higher in ALD group (11.45±0.82 mg/l), than in the NAFLD group (4.35±0.35 mg/l) or in controls (3,60±0,29 mg/l). SsIgА concentration did not depend on adiposity and gender. The ssIgА concentration proved to be increased in Gln223Arg heterozygotes with NAFLD, when compared with controls. However, the frequency of 223Arg and 223Gln alleles was virtually equal in all observed groups with above-normal concentration of ssIgА, as compared to a sub-group with normal ssIgА concentration. Hence, we have not revealed any significant association between Gln223Arg polymorphism of LEPR and ssIgA level. The data obtained will be useful for studying genetic risk factors in development of infectious mucosаl lesions.N. V. Mal’tsevaO. F. LykovaA. V. MorozovaS. V. ArkhipovaYa. A. GorbatovskiiSPb RAACIarticleserum secretory igalepr gene polymorphismhepatic disordersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 5, Pp 465-472 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	serum secretory iga lepr gene polymorphism hepatic disorders Immunologic diseases. Allergy RC581-607
spellingShingle	serum secretory iga lepr gene polymorphism hepatic disorders Immunologic diseases. Allergy RC581-607 N. V. Mal’tseva O. F. Lykova A. V. Morozova S. V. Arkhipova Ya. A. Gorbatovskii SERUM SECRETORY IMMUNOGLOBULIN A AND Gln223Arg POLYMORPHISM OF THE LEPR GENE IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES
description	Level of serum secretory immunoglobulin A was investigated in alcoholic liver disease (ALD, 59 men and 23 women) and non-alcoholic fatty liver disease (NAFLD, 17 men and 93 women).The data were compared with those of persons without liver pathology (control group, 43 men and 73 women). Moreover, we studied possible associations between ssIgA level and Gln223Arg polymorphism of the LEPR gene. Immunological and DNA diagnostics was performed by means of, respectively, ELISA and allele-specific polymerase chain reaction. We have found that the average level of ssIgA was three times higher in ALD group (11.45±0.82 mg/l), than in the NAFLD group (4.35±0.35 mg/l) or in controls (3,60±0,29 mg/l). SsIgА concentration did not depend on adiposity and gender. The ssIgА concentration proved to be increased in Gln223Arg heterozygotes with NAFLD, when compared with controls. However, the frequency of 223Arg and 223Gln alleles was virtually equal in all observed groups with above-normal concentration of ssIgА, as compared to a sub-group with normal ssIgА concentration. Hence, we have not revealed any significant association between Gln223Arg polymorphism of LEPR and ssIgA level. The data obtained will be useful for studying genetic risk factors in development of infectious mucosаl lesions.
format	article
author	N. V. Mal’tseva O. F. Lykova A. V. Morozova S. V. Arkhipova Ya. A. Gorbatovskii
author_facet	N. V. Mal’tseva O. F. Lykova A. V. Morozova S. V. Arkhipova Ya. A. Gorbatovskii
author_sort	N. V. Mal’tseva
title	SERUM SECRETORY IMMUNOGLOBULIN A AND Gln223Arg POLYMORPHISM OF THE LEPR GENE IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES
title_short	SERUM SECRETORY IMMUNOGLOBULIN A AND Gln223Arg POLYMORPHISM OF THE LEPR GENE IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES
title_full	SERUM SECRETORY IMMUNOGLOBULIN A AND Gln223Arg POLYMORPHISM OF THE LEPR GENE IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES
title_fullStr	SERUM SECRETORY IMMUNOGLOBULIN A AND Gln223Arg POLYMORPHISM OF THE LEPR GENE IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES
title_full_unstemmed	SERUM SECRETORY IMMUNOGLOBULIN A AND Gln223Arg POLYMORPHISM OF THE LEPR GENE IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES
title_sort	serum secretory immunoglobulin a and gln223arg polymorphism of the lepr gene in alcoholic and non-alcoholic fatty liver diseases
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/807c19d7a2564b1ea63ead4e4244c3b0
work_keys_str_mv	AT nvmaltseva serumsecretoryimmunoglobulinaandgln223argpolymorphismoftheleprgeneinalcoholicandnonalcoholicfattyliverdiseases AT oflykova serumsecretoryimmunoglobulinaandgln223argpolymorphismoftheleprgeneinalcoholicandnonalcoholicfattyliverdiseases AT avmorozova serumsecretoryimmunoglobulinaandgln223argpolymorphismoftheleprgeneinalcoholicandnonalcoholicfattyliverdiseases AT svarkhipova serumsecretoryimmunoglobulinaandgln223argpolymorphismoftheleprgeneinalcoholicandnonalcoholicfattyliverdiseases AT yaagorbatovskii serumsecretoryimmunoglobulinaandgln223argpolymorphismoftheleprgeneinalcoholicandnonalcoholicfattyliverdiseases
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SERUM SECRETORY IMMUNOGLOBULIN A AND Gln223Arg POLYMORPHISM OF THE LEPR GENE IN ALCOHOLIC AND NON-ALCOHOLIC FATTY LIVER DISEASES

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