Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease

The interactions of heart rate variability and respiratory rate and tidal volume fluctuations provide key information about normal and abnormal sleep. A set of metrics can be computed by analysis of coupling and coherence of these signals, cardiopulmonary coupling (CPC). There are several forms of C...

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Autores principales: Haitham S. Al Ashry, Yuenan Ni, Robert J. Thomas
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Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:80803650188a44aea6f845aac4707f662021-11-12T07:01:11ZCardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease1662-453X10.3389/fnins.2021.755464https://doaj.org/article/80803650188a44aea6f845aac4707f662021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.755464/fullhttps://doaj.org/toc/1662-453XThe interactions of heart rate variability and respiratory rate and tidal volume fluctuations provide key information about normal and abnormal sleep. A set of metrics can be computed by analysis of coupling and coherence of these signals, cardiopulmonary coupling (CPC). There are several forms of CPC, which may provide information about normal sleep physiology, and pathological sleep states ranging from insomnia to sleep apnea and hypertension. As CPC may be computed from reduced or limited signals such as the electrocardiogram or photoplethysmogram (PPG) vs. full polysomnography, wide application including in wearable and non-contact devices is possible. When computed from PPG, which may be acquired from oximetry alone, an automated apnea hypopnea index derived from CPC-oximetry can be calculated. Sleep profiling using CPC demonstrates the impact of stable and unstable sleep on insomnia (exaggerated variability), hypertension (unstable sleep as risk factor), improved glucose handling (associated with stable sleep), drug effects (benzodiazepines increase sleep stability), sleep apnea phenotypes (obstructive vs. central sleep apnea), sleep fragmentations due to psychiatric disorders (increased unstable sleep in depression).Haitham S. Al AshryYuenan NiRobert J. ThomasFrontiers Media S.A.articlecardiopulmonary coupling (CPC)heart rate variabilitysleep apneastable sleepinsomniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution DOAJ
collection DOAJ
language EN
topic cardiopulmonary coupling (CPC)
heart rate variability
sleep apnea
stable sleep
insomnia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
spellingShingle cardiopulmonary coupling (CPC)
heart rate variability
sleep apnea
stable sleep
insomnia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Haitham S. Al Ashry
Yuenan Ni
Robert J. Thomas
Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease
description The interactions of heart rate variability and respiratory rate and tidal volume fluctuations provide key information about normal and abnormal sleep. A set of metrics can be computed by analysis of coupling and coherence of these signals, cardiopulmonary coupling (CPC). There are several forms of CPC, which may provide information about normal sleep physiology, and pathological sleep states ranging from insomnia to sleep apnea and hypertension. As CPC may be computed from reduced or limited signals such as the electrocardiogram or photoplethysmogram (PPG) vs. full polysomnography, wide application including in wearable and non-contact devices is possible. When computed from PPG, which may be acquired from oximetry alone, an automated apnea hypopnea index derived from CPC-oximetry can be calculated. Sleep profiling using CPC demonstrates the impact of stable and unstable sleep on insomnia (exaggerated variability), hypertension (unstable sleep as risk factor), improved glucose handling (associated with stable sleep), drug effects (benzodiazepines increase sleep stability), sleep apnea phenotypes (obstructive vs. central sleep apnea), sleep fragmentations due to psychiatric disorders (increased unstable sleep in depression).
format article
author Haitham S. Al Ashry
Yuenan Ni
Robert J. Thomas
author_facet Haitham S. Al Ashry
Yuenan Ni
Robert J. Thomas
author_sort Haitham S. Al Ashry
title Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease
title_short Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease
title_full Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease
title_fullStr Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease
title_full_unstemmed Cardiopulmonary Sleep Spectrograms Open a Novel Window Into Sleep Biology—Implications for Health and Disease
title_sort cardiopulmonary sleep spectrograms open a novel window into sleep biology—implications for health and disease
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/80803650188a44aea6f845aac4707f66
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AT yuenanni cardiopulmonarysleepspectrogramsopenanovelwindowintosleepbiologyimplicationsforhealthanddisease
AT robertjthomas cardiopulmonarysleepspectrogramsopenanovelwindowintosleepbiologyimplicationsforhealthanddisease
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