Task-induced deactivation from rest extends beyond the default mode brain network.

Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations...

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Autores principales:	Ben J Harrison, Jesus Pujol, Oren Contreras-Rodríguez, Carles Soriano-Mas, Marina López-Solà, Joan Deus, Hector Ortiz, Laura Blanco-Hinojo, Pino Alonso, Rosa Hernández-Ribas, Narcís Cardoner, José M Menchón
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8081c6bb3c2d47959f48d11116f25e62
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id	oai:doaj.org-article:8081c6bb3c2d47959f48d11116f25e62
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spelling	oai:doaj.org-article:8081c6bb3c2d47959f48d11116f25e622021-11-18T06:48:59ZTask-induced deactivation from rest extends beyond the default mode brain network.1932-620310.1371/journal.pone.0022964https://doaj.org/article/8081c6bb3c2d47959f48d11116f25e622011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829564/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.Ben J HarrisonJesus PujolOren Contreras-RodríguezCarles Soriano-MasMarina López-SolàJoan DeusHector OrtizLaura Blanco-HinojoPino AlonsoRosa Hernández-RibasNarcís CardonerJosé M MenchónPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e22964 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ben J Harrison Jesus Pujol Oren Contreras-Rodríguez Carles Soriano-Mas Marina López-Solà Joan Deus Hector Ortiz Laura Blanco-Hinojo Pino Alonso Rosa Hernández-Ribas Narcís Cardoner José M Menchón Task-induced deactivation from rest extends beyond the default mode brain network.
description	Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized 'default-mode network' (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes.
format	article
author	Ben J Harrison Jesus Pujol Oren Contreras-Rodríguez Carles Soriano-Mas Marina López-Solà Joan Deus Hector Ortiz Laura Blanco-Hinojo Pino Alonso Rosa Hernández-Ribas Narcís Cardoner José M Menchón
author_facet	Ben J Harrison Jesus Pujol Oren Contreras-Rodríguez Carles Soriano-Mas Marina López-Solà Joan Deus Hector Ortiz Laura Blanco-Hinojo Pino Alonso Rosa Hernández-Ribas Narcís Cardoner José M Menchón
author_sort	Ben J Harrison
title	Task-induced deactivation from rest extends beyond the default mode brain network.
title_short	Task-induced deactivation from rest extends beyond the default mode brain network.
title_full	Task-induced deactivation from rest extends beyond the default mode brain network.
title_fullStr	Task-induced deactivation from rest extends beyond the default mode brain network.
title_full_unstemmed	Task-induced deactivation from rest extends beyond the default mode brain network.
title_sort	task-induced deactivation from rest extends beyond the default mode brain network.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/8081c6bb3c2d47959f48d11116f25e62
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Task-induced deactivation from rest extends beyond the default mode brain network.

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