Epithelioid Trophoblastic Tumour Presenting with Scalp Lesions

Epithelioid trophoblastic tumour (ETT) is a very rare variant of gestational trophoblastic disease, which arises in reproductive-age women with a prior gestational history. Because of its rarity, its biological behaviour, imaging characteristics and therapeutic schedule have not yet been fully estab...

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Autores principales:	Raquel Basto, Inês Brandão Rêgo, Joana Correia Magalhães, Maria João Sousa, Tatiana Cunha Pereira, Sofia Broco, Isabel Pazos, Teresa Carvalho, Gabriela Sousa
Formato:	article
Lenguaje:	EN
Publicado:	SMC MEDIA SRL 2021
Materias:	trophoblastic disease gynecological cancer Medicine R
Acceso en línea:	https://doaj.org/article/8081c6df3a174c829b65675795bf8f98
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spelling	oai:doaj.org-article:8081c6df3a174c829b65675795bf8f982021-11-09T11:21:26ZEpithelioid Trophoblastic Tumour Presenting with Scalp Lesions2284-259410.12890/2021_002870https://doaj.org/article/8081c6df3a174c829b65675795bf8f982021-10-01T00:00:00Zhttps://www.ejcrim.com/index.php/EJCRIM/article/view/2870https://doaj.org/toc/2284-2594Epithelioid trophoblastic tumour (ETT) is a very rare variant of gestational trophoblastic disease, which arises in reproductive-age women with a prior gestational history. Because of its rarity, its biological behaviour, imaging characteristics and therapeutic schedule have not yet been fully established. Here we describe a rare case of metastatic ETT in a premenopausal woman. A 40-year-old, gravida 3, para 2, Portuguese woman was referred to the dermatology department for multiple skin nodules on the scalp measuring between 1 and 6 cm. A skin biopsy was suggestive of metastatic lesions of low differentiated carcinoma in favour of squamous cell carcinoma. Staging cervical-thoracic-abdominal and pelvic CT showed multiple lesions compatible with metastasis (ganglia, lung and kidneys). Since a CT scan was unable to identify the primary tumour, it was decided to perform a PET-CT scan and to take a biopsy of a vulvar nodule which had been clinically identified as ETT. The patient began the EMA-CO protocol and completed two cycles but with clinical worsening and radiological progression. Although several different chemotherapy regimens are used to treat gestational trophoblastic disease, the optimal treatment is not known given the rarity of this disease and the lack of controlled trials.Raquel BastoInês Brandão RêgoJoana Correia MagalhãesMaria João SousaTatiana Cunha PereiraSofia BrocoIsabel PazosTeresa CarvalhoGabriela SousaSMC MEDIA SRLarticletrophoblastic disease gynecological cancerMedicineRENEuropean Journal of Case Reports in Internal Medicine (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	trophoblastic disease gynecological cancer Medicine R
spellingShingle	trophoblastic disease gynecological cancer Medicine R Raquel Basto Inês Brandão Rêgo Joana Correia Magalhães Maria João Sousa Tatiana Cunha Pereira Sofia Broco Isabel Pazos Teresa Carvalho Gabriela Sousa Epithelioid Trophoblastic Tumour Presenting with Scalp Lesions
description	Epithelioid trophoblastic tumour (ETT) is a very rare variant of gestational trophoblastic disease, which arises in reproductive-age women with a prior gestational history. Because of its rarity, its biological behaviour, imaging characteristics and therapeutic schedule have not yet been fully established. Here we describe a rare case of metastatic ETT in a premenopausal woman. A 40-year-old, gravida 3, para 2, Portuguese woman was referred to the dermatology department for multiple skin nodules on the scalp measuring between 1 and 6 cm. A skin biopsy was suggestive of metastatic lesions of low differentiated carcinoma in favour of squamous cell carcinoma. Staging cervical-thoracic-abdominal and pelvic CT showed multiple lesions compatible with metastasis (ganglia, lung and kidneys). Since a CT scan was unable to identify the primary tumour, it was decided to perform a PET-CT scan and to take a biopsy of a vulvar nodule which had been clinically identified as ETT. The patient began the EMA-CO protocol and completed two cycles but with clinical worsening and radiological progression. Although several different chemotherapy regimens are used to treat gestational trophoblastic disease, the optimal treatment is not known given the rarity of this disease and the lack of controlled trials.
format	article
author	Raquel Basto Inês Brandão Rêgo Joana Correia Magalhães Maria João Sousa Tatiana Cunha Pereira Sofia Broco Isabel Pazos Teresa Carvalho Gabriela Sousa
author_facet	Raquel Basto Inês Brandão Rêgo Joana Correia Magalhães Maria João Sousa Tatiana Cunha Pereira Sofia Broco Isabel Pazos Teresa Carvalho Gabriela Sousa
author_sort	Raquel Basto
title	Epithelioid Trophoblastic Tumour Presenting with Scalp Lesions
title_short	Epithelioid Trophoblastic Tumour Presenting with Scalp Lesions
title_full	Epithelioid Trophoblastic Tumour Presenting with Scalp Lesions
title_fullStr	Epithelioid Trophoblastic Tumour Presenting with Scalp Lesions
title_full_unstemmed	Epithelioid Trophoblastic Tumour Presenting with Scalp Lesions
title_sort	epithelioid trophoblastic tumour presenting with scalp lesions
publisher	SMC MEDIA SRL
publishDate	2021
url	https://doaj.org/article/8081c6df3a174c829b65675795bf8f98
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Epithelioid Trophoblastic Tumour Presenting with Scalp Lesions

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