Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination

Abstract In this work, we fabricated a novel graphene film composite biosensor for microcystin-LR detection as an alternative to time-consuming, expensive, non-portable and often skills-demanding conventional methods of analysis involved in water quality monitoring and assessment. Excellent linear c...

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Autores principales:	Wei Zhang, Baoping Jia, Hiroaki Furumai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/80855f8fe55e4811a8cd81a5478f3c8b
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spelling	oai:doaj.org-article:80855f8fe55e4811a8cd81a5478f3c8b2021-12-02T16:08:15ZFabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination10.1038/s41598-018-28959-w2045-2322https://doaj.org/article/80855f8fe55e4811a8cd81a5478f3c8b2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28959-whttps://doaj.org/toc/2045-2322Abstract In this work, we fabricated a novel graphene film composite biosensor for microcystin-LR detection as an alternative to time-consuming, expensive, non-portable and often skills-demanding conventional methods of analysis involved in water quality monitoring and assessment. Excellent linear correlation (R 2 = 0.99) of the electron-transfer resistance was achieved over a wide range of microcystin-LR (MC-LR) concentration, i.e. 0.005–10 μg/L. As-prepared graphene film composite biosensors can specifically detect MC-LR with remarkable sensitivity and detection limit (2.3 ng/L) much lower than the World Health Organization (WHO) provisional guideline limit of microcystin-LR concentration (i.e. 1 μg/L) in different water sources. Their great potential can be attributed to large active surface area of graphene film and efficient charge transfer process enabled by their high conductivity. Developed graphene film composite biosensors were also successfully applied to determination of MC-LR in several environmental water samples with high detection recovery, which offers a promising possibility of large-scale manufacture of sensor tips due to their macroscopic free-standing nature, the scalable fabrication route and easily tunable size.Wei ZhangBaoping JiaHiroaki FurumaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei Zhang Baoping Jia Hiroaki Furumai Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
description	Abstract In this work, we fabricated a novel graphene film composite biosensor for microcystin-LR detection as an alternative to time-consuming, expensive, non-portable and often skills-demanding conventional methods of analysis involved in water quality monitoring and assessment. Excellent linear correlation (R 2 = 0.99) of the electron-transfer resistance was achieved over a wide range of microcystin-LR (MC-LR) concentration, i.e. 0.005–10 μg/L. As-prepared graphene film composite biosensors can specifically detect MC-LR with remarkable sensitivity and detection limit (2.3 ng/L) much lower than the World Health Organization (WHO) provisional guideline limit of microcystin-LR concentration (i.e. 1 μg/L) in different water sources. Their great potential can be attributed to large active surface area of graphene film and efficient charge transfer process enabled by their high conductivity. Developed graphene film composite biosensors were also successfully applied to determination of MC-LR in several environmental water samples with high detection recovery, which offers a promising possibility of large-scale manufacture of sensor tips due to their macroscopic free-standing nature, the scalable fabrication route and easily tunable size.
format	article
author	Wei Zhang Baoping Jia Hiroaki Furumai
author_facet	Wei Zhang Baoping Jia Hiroaki Furumai
author_sort	Wei Zhang
title	Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
title_short	Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
title_full	Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
title_fullStr	Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
title_full_unstemmed	Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
title_sort	fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/80855f8fe55e4811a8cd81a5478f3c8b
work_keys_str_mv	AT weizhang fabricationofgraphenefilmcompositeelectrochemicalbiosensorasaprescreeningalgaltoxindetectiontoolintheeventofwatercontamination AT baopingjia fabricationofgraphenefilmcompositeelectrochemicalbiosensorasaprescreeningalgaltoxindetectiontoolintheeventofwatercontamination AT hiroakifurumai fabricationofgraphenefilmcompositeelectrochemicalbiosensorasaprescreeningalgaltoxindetectiontoolintheeventofwatercontamination
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Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination

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