Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer

Yanrong Cai,1 Lieping Guo,2 Hongxing Shen,2 Xiaofei An,2 Hong Jiang,3 Fang Ji,2 Yunfei Niu21The College of Basic Science of Medicine, Hunan University of Traditional Chinese Medicine, Changsha, 2Department of Orthopaedics, Changhai Hospital, Second Military Medical University, 3School of Materials S...

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Autores principales:	Cai Y, Guo L, Shen H, An X, Jian H, Ji F, Niu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/80861f9b5a3c46c68b91945504e3b47a
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spelling	oai:doaj.org-article:80861f9b5a3c46c68b91945504e3b47a2021-12-02T04:28:15ZDegradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer1178-2013https://doaj.org/article/80861f9b5a3c46c68b91945504e3b47a2015-06-01T00:00:00Zhttp://www.dovepress.com/degradability-bioactivity-and-osteogenesis-of-biocomposite-scaffolds-o-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yanrong Cai,1 Lieping Guo,2 Hongxing Shen,2 Xiaofei An,2 Hong Jiang,3 Fang Ji,2 Yunfei Niu21The College of Basic Science of Medicine, Hunan University of Traditional Chinese Medicine, Changsha, 2Department of Orthopaedics, Changhai Hospital, Second Military Medical University, 3School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People’s Republic of ChinaAbstract: Biocomposite scaffolds of lithium (Li)-containing mesoporous bioglass and monomethoxy poly(ethylene glycol)-poly(D,L-lactide-co-glycolide)-poly(L-lysine) (mPEG-PLGA-b-PLL) copolymer were fabricated in this study. The results showed that the water absorption and degradability of Li-containing mesoporous bioglass/mPEG-PLGA-b-PLL composite (l-MBPC) scaffolds were obviously higher than Li-containing bioglass/mPEG-PLGA-b-PLL composite (l-BPC) scaffolds. Moreover, the apatite-formation ability of l-MBPC scaffolds was markedly enhanced as compared with l-BPC scaffolds, indicating that l-MBPC scaffolds containing mesoporous bioglass exhibited good bioactivity. The cell experimental results showed that cell attachment, proliferation, and alkaline phosphatase activity of MC3T3-E1 cells on l-MBPC scaffolds were remarkably improved as compared to l-BPC scaffolds. In animal experiments, the histological elevation results revealed that l-MBPC scaffolds significantly promoted new bone formation, indicating good osteogenesis. l-MBPC scaffolds with improved properties would be an excellent candidate for bone tissue repair.Keywords: MBG, copolymer, degradability, bioactivity, osteogenesis, cell proliferation, bone repairCai YGuo LShen HAn XJian HJi FNiu YDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 4125-4136 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Cai Y Guo L Shen H An X Jian H Ji F Niu Y Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer
description	Yanrong Cai,1 Lieping Guo,2 Hongxing Shen,2 Xiaofei An,2 Hong Jiang,3 Fang Ji,2 Yunfei Niu21The College of Basic Science of Medicine, Hunan University of Traditional Chinese Medicine, Changsha, 2Department of Orthopaedics, Changhai Hospital, Second Military Medical University, 3School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People’s Republic of ChinaAbstract: Biocomposite scaffolds of lithium (Li)-containing mesoporous bioglass and monomethoxy poly(ethylene glycol)-poly(D,L-lactide-co-glycolide)-poly(L-lysine) (mPEG-PLGA-b-PLL) copolymer were fabricated in this study. The results showed that the water absorption and degradability of Li-containing mesoporous bioglass/mPEG-PLGA-b-PLL composite (l-MBPC) scaffolds were obviously higher than Li-containing bioglass/mPEG-PLGA-b-PLL composite (l-BPC) scaffolds. Moreover, the apatite-formation ability of l-MBPC scaffolds was markedly enhanced as compared with l-BPC scaffolds, indicating that l-MBPC scaffolds containing mesoporous bioglass exhibited good bioactivity. The cell experimental results showed that cell attachment, proliferation, and alkaline phosphatase activity of MC3T3-E1 cells on l-MBPC scaffolds were remarkably improved as compared to l-BPC scaffolds. In animal experiments, the histological elevation results revealed that l-MBPC scaffolds significantly promoted new bone formation, indicating good osteogenesis. l-MBPC scaffolds with improved properties would be an excellent candidate for bone tissue repair.Keywords: MBG, copolymer, degradability, bioactivity, osteogenesis, cell proliferation, bone repair
format	article
author	Cai Y Guo L Shen H An X Jian H Ji F Niu Y
author_facet	Cai Y Guo L Shen H An X Jian H Ji F Niu Y
author_sort	Cai Y
title	Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer
title_short	Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer
title_full	Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer
title_fullStr	Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer
title_full_unstemmed	Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer
title_sort	degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mpeg-plga-b-pll copolymer
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/80861f9b5a3c46c68b91945504e3b47a
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Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer

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