Adult stem cell deficits drive Slc29a3 disorders in mice

Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misregulation of the AMPK-mTOR-ULK axis.

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Autores principales:	Sreenath Nair, Anne M. Strohecker, Avinash K. Persaud, Bhawana Bissa, Shanmugam Muruganandan, Craig McElroy, Rakesh Pathak, Michelle Williams, Radhika Raj, Amal Kaddoumi, Alex Sparreboom, Aaron M. Beedle, Rajgopal Govindarajan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/808693518ee945b095baa8826e112354
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spelling	oai:doaj.org-article:808693518ee945b095baa8826e1123542021-12-02T14:40:19ZAdult stem cell deficits drive Slc29a3 disorders in mice10.1038/s41467-019-10925-32041-1723https://doaj.org/article/808693518ee945b095baa8826e1123542019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10925-3https://doaj.org/toc/2041-1723Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misregulation of the AMPK-mTOR-ULK axis.Sreenath NairAnne M. StroheckerAvinash K. PersaudBhawana BissaShanmugam MuruganandanCraig McElroyRakesh PathakMichelle WilliamsRadhika RajAmal KaddoumiAlex SparreboomAaron M. BeedleRajgopal GovindarajanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sreenath Nair Anne M. Strohecker Avinash K. Persaud Bhawana Bissa Shanmugam Muruganandan Craig McElroy Rakesh Pathak Michelle Williams Radhika Raj Amal Kaddoumi Alex Sparreboom Aaron M. Beedle Rajgopal Govindarajan Adult stem cell deficits drive Slc29a3 disorders in mice
description	Mutations in equilibrative nucleoside transporter 3 (ENT3), encoded by SLC29A3, cause a spectrum of human genetic disorders. Here, the authors show altered haematopoietic stem cell and mesenchymal stem cell fates in ENT3-deficient mice, due to misregulation of the AMPK-mTOR-ULK axis.
format	article
author	Sreenath Nair Anne M. Strohecker Avinash K. Persaud Bhawana Bissa Shanmugam Muruganandan Craig McElroy Rakesh Pathak Michelle Williams Radhika Raj Amal Kaddoumi Alex Sparreboom Aaron M. Beedle Rajgopal Govindarajan
author_facet	Sreenath Nair Anne M. Strohecker Avinash K. Persaud Bhawana Bissa Shanmugam Muruganandan Craig McElroy Rakesh Pathak Michelle Williams Radhika Raj Amal Kaddoumi Alex Sparreboom Aaron M. Beedle Rajgopal Govindarajan
author_sort	Sreenath Nair
title	Adult stem cell deficits drive Slc29a3 disorders in mice
title_short	Adult stem cell deficits drive Slc29a3 disorders in mice
title_full	Adult stem cell deficits drive Slc29a3 disorders in mice
title_fullStr	Adult stem cell deficits drive Slc29a3 disorders in mice
title_full_unstemmed	Adult stem cell deficits drive Slc29a3 disorders in mice
title_sort	adult stem cell deficits drive slc29a3 disorders in mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/808693518ee945b095baa8826e112354
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Adult stem cell deficits drive Slc29a3 disorders in mice

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