MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy.

The bacterium Helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of H. pylori in a murine infection model. We now demonstrate that by...

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Auteurs principaux: Sara K Lindén, Yong H Sheng, Alison L Every, Kim M Miles, Emma C Skoog, Timothy H J Florin, Philip Sutton, Michael A McGuckin
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2009
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Accès en ligne:https://doaj.org/article/8088459c1b2e435baa2308dee51d9eab
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