Effect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination

The current study aimed to determine to what extent prior COVID-19 infection affects the response of specific antibodies following vaccination. The study involved 173 healthcare professionals who completed the two-dose vaccination course with BNT162b2, including 40 who previously experienced clinica...

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Autores principales:	Robert Flisiak, Małgorzata Pawłowska, Magdalena Rogalska-Płońska, Monika Bociąga-Jasik, Krzysztof Kłos, Anna Piekarska, Dorota Zarębska-Michaluk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 SARS-CoV-2 vaccination Medicine R
Acceso en línea:	https://doaj.org/article/808bd8b4161649a7b96aa8aaf3bf90a4
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id	oai:doaj.org-article:808bd8b4161649a7b96aa8aaf3bf90a4
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spelling	oai:doaj.org-article:808bd8b4161649a7b96aa8aaf3bf90a42021-11-25T19:11:20ZEffect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination10.3390/vaccines91113252076-393Xhttps://doaj.org/article/808bd8b4161649a7b96aa8aaf3bf90a42021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1325https://doaj.org/toc/2076-393XThe current study aimed to determine to what extent prior COVID-19 infection affects the response of specific antibodies following vaccination. The study involved 173 healthcare professionals who completed the two-dose vaccination course with BNT162b2, including 40 who previously experienced clinical COVID-19. The levels of anti-SARS-CoV-2 S1S2 IgG (anti-S) and, in some cases, anti-SARS-CoV-S-RBD IgG (anti-S-RBD) were determined six months after complete vaccination. A level exceeding the cut-off values for both anti-S and anti-S-RBD was observed in 100% of subjects, but after setting the analysis to 5- and 10-fold cut-off levels, the percentage of subjects meeting this criterion was significantly higher for anti-S-RBD. The 100-fold cut-off level was achieved by only 21% and 16% for anti-S and anti-S-RBD, respectively. Anti-S and anti-S-RBD levels above ten times the positive cut-off were respectively observed in 91% and 100% individuals with a history of COVID-19, while among those without COVID-19, these values were 64% and 90%, respectively. Significantly higher incidence of values above 10 and 100 times the cut-off became apparent among people with a history of COVID-19. In conclusion, vaccination against COVID-19 following infection with the disease provides higher levels of specific antibodies 6 months after vaccination than those of individuals without a history of the disease, which supports the use of a booster dose, particularly for those who have not experienced SARS-CoV-2 infection.Robert FlisiakMałgorzata PawłowskaMagdalena Rogalska-PłońskaMonika Bociąga-JasikKrzysztof KłosAnna PiekarskaDorota Zarębska-MichalukMDPI AGarticleCOVID-19SARS-CoV-2vaccinationMedicineRENVaccines, Vol 9, Iss 1325, p 1325 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 vaccination Medicine R
spellingShingle	COVID-19 SARS-CoV-2 vaccination Medicine R Robert Flisiak Małgorzata Pawłowska Magdalena Rogalska-Płońska Monika Bociąga-Jasik Krzysztof Kłos Anna Piekarska Dorota Zarębska-Michaluk Effect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination
description	The current study aimed to determine to what extent prior COVID-19 infection affects the response of specific antibodies following vaccination. The study involved 173 healthcare professionals who completed the two-dose vaccination course with BNT162b2, including 40 who previously experienced clinical COVID-19. The levels of anti-SARS-CoV-2 S1S2 IgG (anti-S) and, in some cases, anti-SARS-CoV-S-RBD IgG (anti-S-RBD) were determined six months after complete vaccination. A level exceeding the cut-off values for both anti-S and anti-S-RBD was observed in 100% of subjects, but after setting the analysis to 5- and 10-fold cut-off levels, the percentage of subjects meeting this criterion was significantly higher for anti-S-RBD. The 100-fold cut-off level was achieved by only 21% and 16% for anti-S and anti-S-RBD, respectively. Anti-S and anti-S-RBD levels above ten times the positive cut-off were respectively observed in 91% and 100% individuals with a history of COVID-19, while among those without COVID-19, these values were 64% and 90%, respectively. Significantly higher incidence of values above 10 and 100 times the cut-off became apparent among people with a history of COVID-19. In conclusion, vaccination against COVID-19 following infection with the disease provides higher levels of specific antibodies 6 months after vaccination than those of individuals without a history of the disease, which supports the use of a booster dose, particularly for those who have not experienced SARS-CoV-2 infection.
format	article
author	Robert Flisiak Małgorzata Pawłowska Magdalena Rogalska-Płońska Monika Bociąga-Jasik Krzysztof Kłos Anna Piekarska Dorota Zarębska-Michaluk
author_facet	Robert Flisiak Małgorzata Pawłowska Magdalena Rogalska-Płońska Monika Bociąga-Jasik Krzysztof Kłos Anna Piekarska Dorota Zarębska-Michaluk
author_sort	Robert Flisiak
title	Effect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination
title_short	Effect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination
title_full	Effect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination
title_fullStr	Effect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination
title_full_unstemmed	Effect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination
title_sort	effect of covid-19 on anti-s antibody response in healthcare workers six months post-vaccination
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/808bd8b4161649a7b96aa8aaf3bf90a4
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Effect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination

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