Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation

Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation

AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased glucose consumption and decreased lipid accumulati...

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Autores principales: Min-Sik Lee, Hyun-Ji Han, Su Yeon Han, Il Young Kim, Sehyun Chae, Choong-Sil Lee, Sung Eun Kim, Seul Gi Yoon, Jun-Won Park, Jung-Hoon Kim, Soyeon Shin, Manhyung Jeong, Aram Ko, Ho-Young Lee, Kyoung-Jin Oh, Yun-Hee Lee, Kwang-Hee Bae, Seung-Hoi Koo, Jea-woo Kim, Je Kyung Seong, Daehee Hwang, Jaewhan Song
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/808f9e7ecce2423aa60cf5a7715788c6
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Sumario:AMPK activation has been suggested as treatment for obesity and its complications. Here the authors show that the ubiquitin ligase MKRN1 binds to AMPK and mediates its ubiquitination and degradation. Loss of MKRN1 leads to AMPK activation, increased glucose consumption and decreased lipid accumulation.

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